Breaking Bad: the Structure and Function of the Blood-Brain Barrier in Epilepsy
| Autor: | Dana Ekstein, Hadas Han, Sara Eyal, Aniv Mann |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell type Pharmaceutical Science Status epilepticus Disease Pharmacology Blood–brain barrier 03 medical and health sciences Epilepsy 0302 clinical medicine Pharmacotherapy Medicine Animals Humans business.industry medicine.disease 030104 developmental biology medicine.anatomical_structure nervous system Drug development Blood-Brain Barrier cardiovascular system Etiology Anticonvulsants medicine.symptom business Neuroscience 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | The AAPS journal. 19(4) |
| ISSN: | 1550-7416 |
| Popis: | Epilepsy is a neurological disease with variable etiology and clinical manifestation, affecting more than 50 million people worldwide. Although the ultimate precipitators of seizures are neurons, it is becoming evident that epileptic activity is associated with changes in the function of other cell types, including those consisting the blood-brain barrier (BBB) and regulating its permeability. The interrelationships between impaired BBB function and epilepsy are complex, as BBB dysfunction may both lead to seizures and be induced by epileptic activity. In this article, we review alterations in key BBB properties that have been found in patients with epilepsy and in animal models of the disease. We highlight emerging biomarkers for individualized treatment, implications for pharmacotherapy, and potential BBB-related targets for drug development. |
| Databáze: | OpenAIRE |
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