Two novel microbial conversion products of progesterone derivatives
| Autor: | Dirk Kirschenowski, Klaus Kieslich |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Magnetic Resonance Spectroscopy
medicine.medical_treatment Metabolite Microorganism Clinical Biochemistry Hydroxylation Biochemistry Steroid chemistry.chemical_compound Endocrinology Biotransformation Hydroxyprogesterones medicine Molecular Biology Progesterone Pharmacology Molecular Structure biology 17-alpha-Hydroxyprogesterone Organic Chemistry Fungi imperfecti Algestone biology.organism_classification Corynespora Trichothecium roseum chemistry Fermentation Mitosporic Fungi |
| Zdroj: | Steroids. 58:278-281 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/0039-128x(93)90073-v |
| Popis: | Two novel microbial steroid hydroxylations were found in a screening of 131 microorganisms under aerobic conditions. 17 alpha-Hydroxyprogesterone was hydroxylated in the 8 beta-position by Corynespora melonis CBS 16260, and fermentation of 17 alpha-acetoxyprogesterone with Pycnosporium species ATCC 12231 yielded 11 beta-hydroxy- and 11 beta, 12 beta-dihydroxy-17 alpha-acetoxyprogesterone. The known 11 beta-hydroxy compound could be obtained as a single product with Trichothecium roseum ATCC 12519. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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