Carotid Intima-Media Thickness
| Autor: | Laura M. Lyall, Joey Ward, Rona J. Strawbridge, Daniel J. Smith, Richard J. Shaw, Breda Cullen, Amy Ferguson, Mark E.S. Bailey, Nicholas Graham, Rachana Tank, Robert Pearsall, Jill P. Pell, Donald M. Lyall, Keira J.A. Johnston |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Intima-media thickness Disease Coronary artery disease Carotid Intima-Media Thickness Body Mass Index 0302 clinical medicine Risk Factors Biological Specimen Banks 2. Zero hunger 0303 health sciences Incidence Diabetes Middle Aged Sex specific Biobank 3. Good health Carotid Arteries Phenotype Cardiovascular Diseases cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine Type 2 medicine.medical_specialty Vascular Remodeling Risk Assessment Article 03 medical and health sciences Diabetes mellitus Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Obesity cardiovascular diseases Association studies 030304 developmental biology Genetic association business.industry Atherosclerosis medicine.disease United Kingdom Genetic Loci business Carotid artery 030217 neurology & neurosurgery Genome-Wide Association Study |
| Zdroj: | Arterioscler Thromb Vasc Biol Strawbridge, R J, Ward, J, Bailey, M E S, Cullen, B, Ferguson, A, Graham, N, Johnston, K J A, Lyall, L M, Pearsall, R, Pell, J, Shaw, R J, Tank, R, Lyall, D M & Smith, D J 2019, ' Carotid intima-media thickness novel loci, sex-specific effects, and genetic correlations with obesity and glucometabolic traits in UK Biobank ', Arteriosclerosis, Thrombosis, and Vascular Biology, pp. 446-461 . https://doi.org/10.1161/ATVBAHA.119.313226 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/atvbaha.119.313226 |
| Popis: | Objective: Atherosclerosis is the underlying cause of most cardiovascular disease, but mechanisms underlying atherosclerosis are incompletely understood. Ultrasound measurement of the carotid intima-media thickness (cIMT) can be used to measure vascular remodeling, which is indicative of atherosclerosis. Genome-wide association studies have identified many genetic loci associated with cIMT, but heterogeneity of measurements collected by many small cohorts have been a major limitation in these efforts. Here, we conducted genome-wide association analyses in UKB (UK Biobank; N=22 179), the largest single study with consistent cIMT measurements. Approach and Results: We used BOLT-LMM software to run linear regression of cIMT in UKB, adjusted for age, sex, and genotyping chip. In white British participants, we identified 5 novel loci associated with cIMT and replicated most previously reported loci. In the first sex-specific analyses of cIMT, we identified a locus on chromosome 5, associated with cIMT in women only and highlight VCAN as a good candidate gene at this locus. Genetic correlations with body mass index and glucometabolic traits were also observed. Two loci influenced risk of ischemic heart disease. ConclusionS: These findings replicate previously reported associations, highlight novel biology, and provide new directions for investigating the sex differences observed in cardiovascular disease presentation and progression. |
| Databáze: | OpenAIRE |
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