SARS-CoV-2 placentitis: An uncommon complication of maternal COVID-19

Autor: Susan Dineen, Brendan Fitzgerald, Laura Linehan, Jessica White, Keelin O'Donoghue, John R. Higgins
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Adult
0301 basic medicine
medicine.medical_specialty
Placenta Diseases
Coronavirus disease 2019 (COVID-19)
Placenta
Pregnancy Trimester
Third
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Reduced fetal movements
Review
03 medical and health sciences
0302 clinical medicine
Placentitis
Pregnancy
Histiocytic intervillositis
Obstetrics and Gynaecology
medicine
Humans
Pregnancy Complications
Infectious
skin and connective tissue diseases
Fetus
030219 obstetrics & reproductive medicine
SARS-CoV-2
business.industry
Transmission (medicine)
Obstetrics
fungi
COVID-19
Obstetrics and Gynecology
medicine.disease
Placental pathology
body regions
030104 developmental biology
medicine.anatomical_structure
Reproductive Medicine
Vertical transmission
Female
business
Complication
Developmental Biology
Zdroj: Placenta
ISSN: 0143-4004
DOI: 10.1016/j.placenta.2021.01.012
Popis: We present a case of third trimester pregnancy complicated by SARS-CoV-2 infection and subsequent reduced fetal movements, resulting in emergency Caesarean delivery with demonstrable placental SARS-CoV-2 placentitis. We show through illustration of this case and literature review that SARS-Co-V-2 placentitis is an uncommon but readily recognisable complication of maternal SARS-CoV-2 infection that may be a marker of potential vertical transmission and that may have the capacity to cause fetal compromise through a direct injurious effect on the placenta.
Highlights • We present a pregnancy complicated by SARS-CoV-2 infection and resultant placentitis. • 25% of the parenchyma comprised a deposition similar to perivillous fibrinoid. • Under microscopy, these areas were predominantly a histiocytic intervillositis. • Immunohistochemistry for SARS-CoV-2 showed extensive, strong positive staining. • Reported COVID-19 chronic intervillositis cases depict virus in syncytiotrophoblast.
Databáze: OpenAIRE
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