Influence of low-density lipoprotein cholesterol on virological response to telaprevir-based triple therapy for chronic HCV genotype 1b infection
| Autor: | Eiji Kajiwara, Akira Kawano, Yuichi Tanabe, Norihiro Furusyo, Takeaki Satoh, Makoto Nakamuta, Kazufumi Dohmen, Kazuhiro Takahashi, Hideyuki Nomura, Eiichi Ogawa, Kazuhiro Kotoh, Jun Hayashi, Shinji Shimoda, Koichi Azuma |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Genotype Hepacivirus Logistic regression Antiviral Agents Gastroenterology Telaprevir chemistry.chemical_compound Genotype 1b Recurrence Risk Factors Pegylated interferon Virology Internal medicine medicine Humans Prospective Studies Aged Pharmacology Receiver operating characteristic business.industry Ribavirin virus diseases Cholesterol LDL Hepatitis C Odds ratio Hepatitis C Chronic Middle Aged Prognosis medicine.disease digestive system diseases Treatment Outcome chemistry Immunology Drug Therapy Combination Female business Oligopeptides medicine.drug |
| Zdroj: | Antiviral Research. 104:102-109 |
| ISSN: | 0166-3542 |
| DOI: | 10.1016/j.antiviral.2014.01.004 |
| Popis: | Elevated serum low-density lipoprotein cholesterol (LDL-C) level has been associated with sustained virological response (SVR) by chronic hepatitis C patients treated with pegylated-interferon (PEG-IFN) α and ribavirin (RBV). The aim of this study was to investigate the relation between the baseline LDL-C level and the treatment outcome from telaprevir (TVR)-based triple therapy. This prospective, multicenter study consisted of 241 treatment-experienced patients infected with HCV genotype 1b. All received 12 weeks of TVR in combination with 24 weeks of PEG-IFNα2b and RBV. The SVR rate was 81.3% (196 of 241) by intention-to-treat analysis. Higher LDL-C level was strongly associated with SVR (P=1.3×10⁻⁸). The area under the receiver operating characteristic curve for predicting SVR was 0.78 and the cutoff value for the LDL-C level at baseline was 95 mg/dL. In multivariable logistic regression analysis of predictors of SVR, LDL-C ≥95 mg/dL (odds ratio [OR] 3.60, P=0.0238), α-fetoprotein ≤5.0 ng/mL (OR 5.06, P=0.0060), prior relapse to PEG-IFNα and RBV (OR 5.71, P=0.0008), and rapid virological response (HCV RNA undetectable at week 4) (OR 5.52, P=0.0010) were extracted as independent predictors of SVR. For prior partial and null responders, the SVR rates of the groups with LDL-C ≥95 mg/dL were significantly higher than those of the |
| Databáze: | OpenAIRE |
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