Successful Optimization of Adalimumab Therapy in Refractory Uveitis Due to Behcet's Disease

Autor: Ignacio García-De La Torre, Esperanza Pato, Esteban Rubio-Romero, Marisa Hernandez Garfella, F. Javier Toyos-Sáenz de Miera, Alfredo Adán, Emma Beltrán, Vanesa Calvo-Río, Javier Loricera, José M. Herreras, Javier Manero, Francisco Javier López Longo, José Luis Martín-Varillas, Oscar Ruiz-Moreno, Marina Mesquida, Santiago Muñoz-Fernández, Myriam Gandía Martinez, José-Luis Callejas-Rubio, Juan Sánchez-Bursón, O. Maíz, R. Demetrio-Pablo, Roberto Gallego, M.A. Caracuel, Elia Valls Pascual, Joan M. Nolla, Ricardo Blanco, Belén Atienza-Mateo, José L. Hernández, Miguel Cordero-Coma, Marcelino Revenga, David Díaz-Valle, Carmen González-Vela, José L. García-Serrano, Ana Blanco, Fernando Gamero, Norberto Ortego, Maria Victoria Hernández, Elena Aurrecoechea, Manuel Díaz-Llopis, Miguel A. González-Gay, Enrique Minguez, Agusti Sellas-Fernández, Carmen Carrasco-Cubero, Ángel García-Aparicio, Lucía Martínez-Costa, David Salom, Alejandro Olivé, J. Vazquez
Rok vydání: 2018
Předmět:
Zdroj: OPHTHALMOLOGY
r-FIHGUV. Repositorio Institucional de Producción Científica de la Fundación de Investigación del Hospital General de Valencia
instname
Ophthalmology
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-FISABIO. Repositorio Institucional de Producción Científica
ISSN: 0161-6420
Popis: Purpose: To assess efficacy, safety, and cost-effectiveness of adalimumab (ADA) therapy optimization in a large series of patients with uveitis due to Behcet disease (BD) who achieved remission after the use of this biologic agent. Design: Open-label multicenter study of ADA-treated patients with BD uveitis refractory to conventional immunosuppressants. Subjects: Sixty-five of 74 patients with uveitis due to BD, who achieved remission after a median ADA duration of 6 (range, 3-12) months. ADA was optimized in 23 (35.4%) of them. This biologic agent was maintained at a dose of 40 mg/subcutaneously/2 weeks in the remaining 42 patients. Methods: After remission, based on a shared decision between the patient and the treating physician, ADA was optimized. When agreement between patient and physician was reached, optimization was performed by prolonging the ADA dosing interval progressively. Comparison between optimized and nonoptimized patients was performed. Main Outcome Measures: Efficacy, safety, and cost-effectiveness in optimized and nonoptimized groups. To determine efficacy, intraocular inflammation (anterior chamber cells, vitritis, and retinal vasculitis), macular thickness, visual acuity, and the sparing effect of glucocorticoids were assessed. Results: No demographic or ocular differences were found at the time of ADA onset between the optimized and the nonoptimized groups. Most ocular outcomes were similar after a mean +/- standard deviation follow-up of 34.7+/-13.3 and 26+/-21.3 months in the optimized and nonoptimized groups, respectively. However, relevant adverse effects were only seen in the nonoptimized group (lymphoma, pneumonia, severe local reaction at the injection site, and bacteremia by Escherichia coli, 1 each). Moreover, the mean ADA treatment costs were lower in the optimized group than in the nonoptimized group (6101.25 euros/patient/year vs. 12 339.48; P < 0.01). Conclusion: ADA optimization in BD uveitis refractory to conventional therapy is effective, safe, and costeffective. (C) 2018 by the American Academy of Ophthalmology
Databáze: OpenAIRE
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