Factor XII deficiency evaluated by thrombin generation assay
| Autor: | Marie Hélène Chrétien, Pierre Chamouni, Paul Billoir, Fiston Kasonga, Virginie Barbay, Sabine Brunel, Marielle Fresel, Guillaume Feugray, Véronique Le Cam Duchez |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Factor XII Deficiency medicine.medical_treatment Clinical Biochemistry Inflammation Coagulation Factor XII Tissue factor Internal medicine Fibrinolysis medicine Humans Platelet-poor plasma Aged Retrospective Studies medicine.diagnostic_test business.industry Thrombin General Medicine Middle Aged medicine.disease Thrombosis Endocrinology Coagulation Female Partial Thromboplastin Time medicine.symptom business Partial thromboplastin time |
| Zdroj: | Clinical biochemistry. 100 |
| ISSN: | 1873-2933 |
| Popis: | INTRODUCTION Coagulation factor XII (FXII) plays a role in thrombin generation, fibrinolysis, inflammation, angiogenesis, chemotaxis and diapedesis. FXII deficiency is not associated with bleeding risk unlike other coagulation factors. MATERIALS/METHODS We investigated thrombin generation assay (TGA) profile modification in FXII deficiency and the correlation with TGA and deficiency severity. TGA was performed in platelet poor plasma (PPP) with tissue factor (1 pmol/L) and phospholipid (4 µmol/L) standardized concentration. Thrombin generation profiles were compared in 54 patients with FXII deficiency, 25 healthy controls and 23 patients with hemophilia A (factor VIII (FVIII) deficiency. Patients with FXII deficiency were classified in three groups based on FXII activity (30-50%, 10-29% |
| Databáze: | OpenAIRE |
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