Clinicopathological characteristics and prognostic factors of primary pulmonary lymphoma
| Autor: | Lei Liu, Moyan Zhang, Shugeng Gao, Qi Xue, Guangyu Bai, Huayu He, Fengwei Tan, Yue Peng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Chemotherapy Univariate analysis business.industry medicine.medical_treatment MALT lymphoma Primary pulmonary lymphoma medicine.disease Gastroenterology Lymphoma Radiation therapy Internal medicine medicine Original Article Stage (cooking) business Cohort study |
| Zdroj: | J Thorac Dis |
| ISSN: | 2077-6624 2072-1439 |
| Popis: | BACKGROUND: Primary pulmonary lymphoma (PPL) is a rare extranodal lymphoma originating from the lung, accounting for 0.5–1.0% of primary lung malignant tumors. Previous case reports or cohort studies included a limited sample size; therefore, the understanding of the disease remains inadequate, and clinical data regarding PPL are limited. METHODS: Patients with PPL diagnosed histologically and radiologically between January 2000 and December 2019 at our center were retrospectively analyzed. RESULTS: In total, 90 consecutive cases were included in this research. Forty-seven (52.2%) patients were female, and the median age was 54 years old. Non-Hodgkin’s lymphoma (PPNHL) was the most common type of PPL (71/90, 78.9%), and mucosa-associated lymphoid tissue (MALT) lymphoma was the most common pathological subtype of PPNHL (56.3%) followed by diffuse large B-cell lymphoma (DLBCL) (32.4%). Thirty-nine (43.3%) patients underwent surgical treatment, and the others received chemotherapy alone or combined with radiotherapy. The estimated 5-year overall survival (OS) rates of MALT lymphoma and non-MALT lymphoma were 68.9% and 65.9%, respectively. Univariate analysis of PPL showed that clinicopathological features that significantly correlated with worse OS were age over 60 years (P=0.006 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|