A snapshot of the prevalence of endocrine disorders in pregnancies complicated by coronavirus disease 2019: A narrative review with meta-analysis
| Autor: | Vanessa Krebs Genro, Maria Lúcia Rocha Oppermann, Vânia N. Hirakata, Angela de Azevedo Jacob Reichelt |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Endocrine System Diseases law.invention 03 medical and health sciences 0302 clinical medicine law Pregnancy Diabetes mellitus medicine Prevalence Endocrine system Humans 030212 general & internal medicine Obesity Pregnancy Complications Infectious 030219 obstetrics & reproductive medicine business.industry SARS-CoV-2 Pregnancy Outcome Obstetrics and Gynecology COVID-19 General Medicine medicine.disease Intensive care unit Confidence interval Hospitalization Relative risk Meta-analysis Hyperglycemia Female business |
| Zdroj: | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 154(2) |
| ISSN: | 1879-3479 |
| Popis: | BACKGROUND: Some maternal characteristics indicate worse prognosis in pregnant women with coronavirus disease 2019 (COVID-19). OBJECTIVE: To describe the prevalence of endocrine disorders in pregnancies involving COVID-19, and its impact on maternal outcomes. SEARCH STRATEGY: Search terms were "pregnancy" and "COVID-19". SELECTION: PubMed, Embase, medRxiv, and Cochrane worksheet from February to July 2020 were searched. DATA COLLECTION AND ANALYSIS: Articles describing endocrine disorders in pregnancies with and without COVID-19 involvement were considered. We performed meta-analyses of prevalence using random-effect models and estimated relative risk and 95% confidence intervals (CI) of maternal outcomes relative to presence of endocrine disorders. MAIN RESULTS: Articles included (n = 141) were divided into three data sets: individual (119 articles, 356 women), case series (17 articles, 1064 women), and national registries (7 articles, 10 178 women). Prevalence of obesity ranged from 16% to 46% and hyperglycemia in pregnancy (HIP) ranged from 8% to 12%. In data set 1, HIP and obesity were risk factors for severe disease in crude and age-adjusted models, although not for intensive care unit admission. In data from two national registries, risk of dying was 5.62 (95% CI 0.30-105.95) in women with diabetes and 2.26 (95% CI 1.03-4.96) in those with obesity. CONCLUSION: Obesity and HIP were prevalent in pregnant women with severe COVID-19. |
| Databáze: | OpenAIRE |
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