Oxidative Amination of Cuprated Pyrimidine and Purine Derivatives

Autor:	Paul Knochel, Srinivas Reddy Dubbaka, Nadège Boudet
Rok vydání:	2008
Předmět:	Pyrimidine Adenine Organic Chemistry Chloranil Regioselectivity RNA Uracil Biochemistry Combinatorial chemistry Thymine chemistry.chemical_compound Pyrimidines chemistry Purines Physical and Theoretical Chemistry Oxidation-Reduction Copper Amination DNA
Zdroj:	Organic Letters. 10:1715-1718
ISSN:	1523-7052 1523-7060
Popis:	Using regioselective cuprations (via magnesiations), various primary, secondary and tertiary aminated pyrimidine and purine derivatives were prepared by the oxidative coupling of lithium amidocuprates using chloranil. DNA and RNA units such as aminated uracil or thymine, and adenine, as well as a CDK inhibitor, purvalanol A, were all obtained under mild conditions and satisfactory yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d377e31c455f67a318b30d1826a1c9f5 https://doi.org/10.1021/ol800353s Zobrazit plný text záznamu