Cutting Edge: Epigenetic Regulation of Foxp3 Defines a Stable Population of CD4+ Regulatory T Cells in Tumors from Mice and Humans
| Autor: | Kin-Ming Lo, Nicholas S. Wilson, Kenneth W. Hance, Robert Tighe, Helen Sabzevari, Robert Hofmeister, Yan Lan, Dong Zhang, Jeremy D. Waight, Shinji Takai, Guozhong Qin, Bo Marelli |
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| Rok vydání: | 2015 |
| Předmět: |
Immunology
Population Mice Transgenic chemical and pharmacologic phenomena Biology T-Lymphocytes Regulatory Epigenesis Genetic Immunophenotyping Mice Lymphocytes Tumor-Infiltrating Immune system Transforming Growth Factor beta Cell Line Tumor Neoplasms medicine Animals Humans Immunology and Allergy Epigenetics education Autoimmune disease Regulation of gene expression education.field_of_study FOXP3 Forkhead Transcription Factors hemic and immune systems Transforming growth factor beta DNA Methylation medicine.disease Gene Expression Regulation Neoplastic Disease Models Animal Antigens Surface biology.protein Cutting Edge CpG Islands |
| Zdroj: | The Journal of Immunology. 194:878-882 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | CD4+ regulatory T cells (Tregs) are critical for maintaining self-tolerance and function to prevent autoimmune disease. High densities of intratumoral Tregs are generally associated with poor patient prognosis, a correlation attributed to their broad immune-suppressive features. Two major populations of Tregs have been defined, thymically derived natural Tregs (nTregs) and peripherally induced Tregs (iTregs). However, the relative contribution of nTregs versus iTregs to the intratumoral Treg compartment remains controversial. Demarcating the proportion of nTregs versus iTregs has important implications in the design of therapeutic strategies to overcome their antagonistic effects on antitumor immune responses. We used epigenetic, phenotypic, and functional parameters to evaluate the composition of nTregs versus iTregs isolated from mouse tumor models and primary human tumors. Our findings failed to find evidence for extensive intratumoral iTreg induction. Rather, we identified a population of Foxp3-stable nTregs in tumors from mice and humans. |
| Databáze: | OpenAIRE |
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