A Facile, Improved Synthesis of Sildenafil and Its Analogues

Autor:	Chandiran Takshinamoorthy, Garaga Srinivas, Badarinadh Gupta Peruri, Ambati V. Raghava Reddy, Andra Naidu
Rok vydání:	2015
Předmět:	Chemistry Sildenafil sildenafil Pharmaceutical Science High resolution Chlorosulfonic acid Mass spectrometry novel analogues Article respiratory tract diseases chemistry.chemical_compound Thionyl chloride Yield (chemistry) cardiovascular system Organic chemistry chlorosulfonation Nuclear chemistry
Zdroj:	Scientia Pharmaceutica Volume 84 Issue 3 Pages 447-455
ISSN:	2218-0532
DOI:	10.3390/scipharm84030447
Popis:	This paper describes the facile synthesis of sildenafil citrate (1) and its related compounds through an improved chlorosulfonation reaction using chlorosulfonic acid and thionyl chloride. This synthesis results in pure sildenafil with high yield. The structures of the compounds were determined with infrared (IR), 1H-NMR and 13C-NMR spectroscopic methods, and high resolution mass spectroscopy (HRMS) analysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37662851e014a892c3ee04cb0cd0898 https://doi.org/10.3390/scipharm84030447 Zobrazit plný text záznamu