Self-assembly of BODIPY based pH-sensitive near-infrared polymeric micelles for drug controlled delivery and fluorescence imaging applications
| Autor: | Zhuang Liu, Xiaojun Li, Bizheng Chen, Lifen Zhang, Zhenping Cheng, Xiaodong Liu, Xiulin Zhu, Yu-Jie Xu |
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| Rok vydání: | 2015 |
| Předmět: |
Boron Compounds
Materials science Optical Imaging Chain transfer Hydrogen-Ion Concentration Photochemistry Methacrylate Micelle Polyethylene Glycols chemistry.chemical_compound Polymethacrylic Acids chemistry Methacrylic acid Doxorubicin Delayed-Action Preparations Drug delivery Copolymer Humans Methacrylates General Materials Science BODIPY Ethylene glycol Micelles HeLa Cells |
| Zdroj: | Nanoscale. 7:16399-16416 |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/c5nr04655f |
| Popis: | Responsive block copolymer micelles emerging as promising imaging and drug delivery systems show high stability and on-demand drug release activities. Herein, we developed self-assembled pH-responsive NIR emission micelles entrapped with doxorubicin (DOX) within the cores by the electrostatic interactions for fluorescence imaging and chemotherapy applications. The block copolymer, poly(methacrylic acid)-block-poly[(poly(ethylene glycol) methyl ether methacrylate)-co-boron dipyrromethene derivatives] (PMAA-b-P(PEGMA-co-BODIPY), was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, and the molecular weight distribution of this copolymer was narrow (Mw/Mn = 1.31). The NIR fluorescence enhancement induced by the phenol/phenolate interconversion equilibrium works as a switch in response to the intracellular pH fluctuations. DOX-loaded PMAA-b-P(PEGMA-co-BODIPY) micelles can detect the physiological pH fluctuations with a pKa near physiological conditions (∼7.52), and showed pH-responsive collapse and an obvious acid promoted anticancer drug release behavior (over 58.8-62.8% in 10 h). Real-time imaging of intracellular pH variations was performed and a significant chemotherapy effect was demonstrated against HeLa cells. |
| Databáze: | OpenAIRE |
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