Protective Effects of Astaxanthin on the Levels of Urea and Creatinine as well as Changes in Kidney Tissue following Cadmium-Induced Toxicity in Syrian Male Mice
| Autor: | Fereshteh Mir Mohammadrezaei, Akbar Hajizadeh Moghadam, Nazanin Fathi |
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| Rok vydání: | 2020 |
| Předmět: |
inorganic chemicals
lcsh:R5-920 medicine.medical_specialty Cadmium Kidney Creatinine mice cadmium Chemistry lcsh:R kidney tissue lcsh:Medicine chemistry.chemical_element Male mice urea astaxanthin chemistry.chemical_compound medicine.anatomical_structure Endocrinology Astaxanthin Internal medicine Toxicity medicine Urea lcsh:Medicine (General) |
| Zdroj: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, Vol 28, Iss 5, Pp 33-42 (2020) |
| ISSN: | 2588-3135 1563-4728 |
| DOI: | 10.29252/sjimu.28.5.33 |
| Popis: | Introduction: Cadmium is an environmental and industrial pollutant that causes nephrotoxicity. Astaxanthin is a carotenoid with antioxidant, anti-apoptotic, and anti-inflammatory properties. This study investigated the protective effect of astaxanthin on the levels of urea and creatinine, as well as kidney tissue in cadmium-induced nephrotoxicity. Materials & Methods: In total, 42 mice were divided into seven groups of control, sham (received saline and olive oil), cadmium (received cadmium at a dose of 1 mg/kg for 14 days [sub-acute] and a dose of 3 mg/kg for 1 day [acute]), and treatments (received a dose of 10 mg/kg astaxanthin for 14 days with 1 mg/kg cadmium along with astaxanthin for 14 days and 3 mg/kg cadmium at the last day). It is worth mentioning that the injection was intraperitoneally and each group included six animals. The levels of creatinine and urea were evaluated in the serum, and the kidney sections were stained with hematoxylin-eosin. Ethics code: IR.UMZ.REC.1397.107 Findings: The results showed a significant increase in the level of urea at an acute dose of cadmium, compared to the sham group (P |
| Databáze: | OpenAIRE |
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