A Novel Endoscopic Marker: Safety Experiments in the Rat Stomach
| Autor: | K. Otsuka, H. Asahi, Y. Akiyama, Akio Sugitachi, R. Tsutsumi, T. Itabashi, N. Uesugi, K. Saito |
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| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty Inflammation Histopathological examination Injections law.invention Carbon particle Rats Sprague-Dawley Chitosan chemistry.chemical_compound law Submucosa Gastroscopy medicine Animals Coloring Agents Viscosity business.industry Stomach Gastroenterology Carbon Rats Severe inflammation medicine.anatomical_structure chemistry Glycerophosphates Microscopy Electron Scanning Electron microscope medicine.symptom Rat Stomach business |
| Zdroj: | Endoscopy. 38:735-738 |
| ISSN: | 1438-8812 0013-726X |
| DOI: | 10.1055/s-2006-925262 |
| Popis: | Background and study aims The study aimed to assess a newly developed endoscopic marker designed to cause only minor inflammatory reactions. Materials and methods Chitosan and carbon powder were used in the marker substance. The product was a viscoelastic solution, which was injected into the submucosa in rat stomach walls. The tissue reactions were then examined histopathologically. The structure of the injected marker substance was examined with electron microscopy into rat stomach walls. India ink, which is currently used as an endoscopic marker, served as the control. Results Histopathological examination showed that inflammatory reactions with the novel agent were remarkably mild in the rat organs, while submucosally applied india ink caused severe inflammation in situ. The electron-microscopic findings showed that the carbon particles used were completely spherical in shape and that the carbon in the marker substance was entrapped in the chitosan networks. The india ink was shown to consist of a mixture of fine carbon particles and adhesive additives. Conclusions The chitosan-carbon solution appears to be a promising endoscopic marker substance, causing significantly reduced inflammation. |
| Databáze: | OpenAIRE |
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