Autoimmune Epilepsy: Some Epilepsy Patients Harbor Autoantibodies to Glutamate Receptors and dsDNA on both Sides of the Blood-brain Barrier, which may Kill Neurons and Decrease in Brain Fluids after Hemispherotomy
| Autor: | Mia Levite, Tally Lerman-Sagie, Dori Pelled, Bruria Ben Zeev, Anthony H. Futerman, Hadassa Goldberg-Stern, Vivian I. Teichberg, Dina Amrom, Denis Verheulpen, Yonatan Ganor, Michael Freilinger, Patrick Van Bogaert |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_treatment Autoimmune Diseases -- immunology Hippocampus Antibodies Antinuclear -- blood Autoantigens Epilepsy Receptors AMPA -- genetics Immunology and Allergy Epilepsy surgery Autoimmune Diseases -- pathology Child Cells Cultured Neurons Cell Death Glutamate Decarboxylase Glutamate receptor Antibodies Antinuclear -- cerebrospinal fluid Autoantibodies -- cerebrospinal fluid General Medicine Sciences bio-médicales et agricoles Hippocampus -- pathology Hemispherectomy Antibodies Anticardiolipin -- blood medicine.anatomical_structure Blood-Brain Barrier beta 2-Glycoprotein I Antibodies Antinuclear Child Preschool Encephalitis -- pathology Encephalitis Female Epilepsy -- surgery Neurons -- pathology Research Article lcsh:Immunologic diseases. Allergy Glutamate Decarboxylase -- immunology Autoimmune Diseases -- surgery Adolescent Receptors AMPA -- immunology Immunology Encephalitis -- surgery Molecular Sequence Data Biology Blood–brain barrier Encephalitis -- immunology snRNP Core Proteins Autoimmune Diseases Blood-Brain Barrier -- immunology medicine Beta 2-Glycoprotein I Humans Epilepsy -- pathology Receptors AMPA Amino Acid Sequence Autoantibodies Glycoproteins SnRNP Core Proteins Autoantibody medicine.disease Glycoproteins -- immunology Antibodies Anticardiolipin -- cerebrospinal fluid Epilepsy -- immunology Antibodies Anticardiolipin Autoantibodies -- blood lcsh:RC581-607 |
| Zdroj: | Clinical and Developmental Immunology, Vol 11, Iss 3-4, Pp 241-252 (2004) Clinical & developmental immunology, 11 (3-4 Clinical and Developmental Immunology |
| ISSN: | 1740-2522 |
| DOI: | 10.1080/17402520400001736 |
| Popis: | PURPOSE: Elucidating the potential contribution of specific autoantibodies (Ab's) to the etiology and/or pathology of some human epilepsies. METHODS: Six epilepsy patients with Rasmussen's encephalitis (RE) and 71 patients with other epilepsies were tested for Ab's to the "B" peptide (amino acids 372-395) of the glutamate/AMPA subtype 3 receptor (GluR3B peptide), double-stranded DNA (dsDNA), and additional autoimmune disease-associated autoantigens, and for the ability of their serum and cerebrospinal-fluid (CSF) to kill neurons. RESULTS: Elevated anti-GluR3B Ab' s were found in serum and CSF of most RE patients, and in serum of 17/71 (24%) patients with other epilepsies. In two RE patients, anti-GluR3B Ab's decreased drastically in CSF following functional-hemispherotomy, in association with seizure cessation and neurological improvement. Serum and CSF of two RE patients, and serum of 12/71 (17%) patients with other epilepsies, contained elevated anti-dsDNA Ab's, the hallmark of systemic-lupus-erythematosus. The sera (but not the CSF) of some RE patients contained also clinically elevated levels of "classical" autoimmune Ab's to glutamic-acid-decarboxylase, cardiolipin, beta2-glycoprotein-I and nuclear-antigens SS-A and RNP-70. Sera and CSF of some RE patients caused substantial death of hippocampal neurons. CONCLUSIONS: Some epilepsy patients harbor Ab's to GluR3 and dsDNA on both sides of the blood-brain barrier, and additional autoimmune Ab's only in serum. Since all these Ab's may be detrimental to the nervous system and/or peripheral organs, we recommend testing for their presence in epilepsy, and silencing their activity in Ab-positive patients. Journal Article Research Support, Non-U.S. Gov't SCOPUS: cp.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|