Isolation and Synthesis of Tryptamine Derivatives from a Symbiotic Bacterium Xenorhabdus nematophilus PC
| Autor: | Seunguk Paik, Seok Burm Choe, Bum Rae Cho, Heai Ku Park, Hong Sik Byun, Seong Il Suh, Myung Kwang Park, Chun Soo Lee, Seong Hoon Jhun |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Tryptamine
Strain (chemistry) Chemistry Nematophin Symbiotic bacterium Xenorhabdus nematophilus General Medicine General Chemistry biochemical phenomena metabolism and nutrition medicine.disease_cause Isolation (microbiology) Microbiology chemistry.chemical_compound Biochemistry Staphylococcus aureus medicine Vancomycin medicine.drug |
| Zdroj: | Bulletin of the Korean Chemical Society. 24:623-626 |
| ISSN: | 0253-2964 |
| DOI: | 10.5012/bkcs.2003.24.5.623 |
| Popis: | Nematophin and its analog incorporating tryptamine unit have been isolated and characterized from strain XR-PC of a symbiotic bacterium Xenorhabdus nematophilus, which was newly isolated from Korean entomopathogenic nematodes. The stereoselective synthesis of these compounds was accomplished, and the relative configurations were determined. Nematophin exhibited potent antibacterial activities over several strains of methicillin-resistant S. aureus (MRSA) comparable to those of vancomycin. |
| Databáze: | OpenAIRE |
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