Comprehensive analysis of ADAMTS13 in patients with liver cirrhosis
| Autor: | Masato Yagita, Hitoshi Yoshiji, Yoshihiro Fujimura, Ayami Isonishi, Masahito Uemura, Seiji Kato, Hiroshi Fukui, Chie Morioka, Hiromichi Ishizashi, Masanori Matsumoto, Tatsuhiro Tsujimoto, Masatoshi Ishikawa, Tomomi Matsuyama, Norio Kurumatani |
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| Rok vydání: | 2008 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis Blotting Western ADAMTS13 Protein Down-Regulation Enzyme-Linked Immunosorbent Assay Severity of Illness Index Gastroenterology Adamts13 activity Liver disease Hepatitis B Chronic Chronic hepatitis Von Willebrand factor hemic and lymphatic diseases Internal medicine von Willebrand Factor medicine Humans In patient Platelet Aged Autoantibodies Purpura Thrombotic Thrombocytopenic biology Platelet Count business.industry Thrombosis Hematology Hepatitis C Chronic Middle Aged medicine.disease ADAMTS13 ADAM Proteins Endocrinology biology.protein Cytokines Female business |
| Zdroj: | Thrombosis and Haemostasis. 99:1019-1029 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1160/th08-01-0006 |
| Popis: | SummaryDecreased plasma ADAMTS13 activity (ADAMTS13:AC) results in the accumulation of unusually large von Willebrand factor multimer (UL-VWFM) and the formation of platelet thrombi. It remains controversial whether or not plasma ADAMTS13:AC decreases in patients with liver cirrhosis (LC), and its relationship to clinical features has not been fully investigated. We measured ADAMTS13:AC and its related parameters in plasma in 33 patients with chronic hepatitis (CH) and in 109 patients with LC. ADAMTS13:AC decreased with increasing severity of liver disease (controls means 100%, CH 87%, Child A-LC 79%, Child B-LC 63%, and Child C-LC 31%), and showed severe deficiency ( |
| Databáze: | OpenAIRE |
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