Effects of adrenalectomy and dexamethasone on hepatic lipid metabolism
| Autor: | H G Wilcox, T G Cole, M Heimberg |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Very low-density lipoprotein Fatty acid metabolism Triglyceride Cholesterol Adrenalectomy medicine.medical_treatment QD415-436 Cell Biology Biochemistry chemistry.chemical_compound Endocrinology chemistry Internal medicine Low-density lipoprotein Ketogenesis medicine Ketone bodies lipids (amino acids peptides and proteins) |
| Zdroj: | Journal of Lipid Research, Vol 23, Iss 1, Pp 81-91 (1982) |
| ISSN: | 0022-2275 |
| DOI: | 10.1016/s0022-2275(20)38176-1 |
| Popis: | The influence of adrenalectomy and dexamethasone on hepatic free fatty acid metabolism was studied in isolated perfused livers from male rats. Adrenalectomy 1 week prior to perfusion did not affect uptake of oleate, output of triglyceride, or rate of ketogenesis compared to sham-operated match-fed controls. Livers from dexamethasone-treated rats (0-2 mg/kg per day for 7 days) removed less oleate from the perfusate, esterified more to total and very low density lipoprotein (VLDL) triglyceride, and oxidized less to ketone bodies, com- pared to match fed controls; additional studies with ( 1 -'4C)oleate confirmed these findings. The output of glucose by livers from dexamethasone-treated rats was also stimulated. The output of VLDL triglyceride was correlated with output of total per- fusate triglyceride (r = 0.77, P < 0.001). Prior to perfusion, dexamethasone livers accumulated more triglyceride than did control livers. Adrenalectomy did not affect the concentration of plasma free fatty acid or blood ketones and glucose; however, the plasma concentration of triglyceride was elevated. Dexa- methasone increased the concentration of plasma free fatty acid, total triglyceride, and VLDL protein, triglyceride, phospho- lipid, and free cholesterol. No changes were observed in the concentration or composition of plasma low density lipoprotein (LDL) lipids. The concentration of plasma high density lipo- protein (HDL) protein and lipid, and plasma apoA-I, tended to increase; the ratio of total HDL cholesterol to LDL choles- terol was elevated with dexamethasone treatment. These ob- servations suggest that augmented synthesis and secretion of VLDL triglyceride contribute to glucocorticoid-induced hyper- trig1yceridemia.-Cole, T. G., H. G. Wilcox, and M. Heim- berg. Effects of adrenalectomy and dexamethasone on hepatic lipid metabolism. J. Lipid Res. 1982. 23 81-91. |
| Databáze: | OpenAIRE |
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