The International Testicular Cancer Linkage Consortium: A Clinicopathologic Descriptive Analysis of 461 Familial Malignant Testicular Germ Cell Tumor Kindred
| Autor: | Ludmila Liubchenko, Michael R. Stratton, Katherine M. Tucker, Sergei Tjulandin, Robert Huddart, Gedske Daugaard, Hans Stoll, Catherine Bonaïti-Pellié, Kelly-Anne Phillips, Douglas F. Easton, Larissa A. Korde, Ketil Heimdal, Sophie D. Fosså, Radka Lohynska, Peter Albers, Peter A. Daly, E. Olah, István Bodrogi, Axel Heidenreich, David W. Hogg, Parry Guilford, Darshna Dudakia, Walter P. Weber, Michael Friedlander, Katherine L. Nathanson, Elizabeth A. Rapley, Mark H. Greene, Lawrence H. Einhorn, D. Timothy Bishop, Stéphane Richard, Michael A.S. Jewett, Phuong L. Mai, Lajos Géczi |
|---|---|
| Přispěvatelé: | University of Groningen |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Testicular neoplasms Epidemiology Urology Cousin Population Testicular Germ Cell Tumor Hernia Inguinal Clinicopathologic characteristics Article Familial Internal medicine Cryptorchidism medicine Humans ANTICIPATION education Testicular cancer POPULATION Gynecology FATHER education.field_of_study business.industry TESTIS Family aggregation Cancer Seminoma Neoplasms Germ Cell and Embryonal medicine.disease SUSCEPTIBILITY GENES Malignant Testicular Germ Cell Tumor OF-THE-LITERATURE RISK-FACTORS EXPERIENCE business |
| Zdroj: | Urologic Oncology-Seminars and Original Investigations, 28(5), 492-499. ELSEVIER SCIENCE INC |
| ISSN: | 1078-1439 |
| Popis: | Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population. Materials and methods: Families with >= 2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families. Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism. TGCT was more likely to occur in the ipsilateral testis (kappa = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families. Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial eases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation. Published by Elsevier Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect