Cambrian origin of the CYP27C1-mediated vitamin A1-to-A2 switch, a key mechanism of vertebrate sensory plasticity
| Autor: | M. Carter Cornwall, Ala Morshedian, Stephen D. McCormick, Rikard Frederiksen, Jennifer M. Enright, Gordon L. Fain, Gabriel E. Pollock, Joseph C. Corbo, Matthew B. Toomey |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Vitamin genetic structures Period (gene) Sensory system 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine biology.animal medicine 14. Life underwater lcsh:Science Multidisciplinary Retinal pigment epithelium biology Lamprey visual ecology Vertebrate Biology (Whole Organism) Anatomy biology.organism_classification photoreceptor 030104 developmental biology medicine.anatomical_structure Petromyzon chemistry Rhodopsin Evolutionary biology Petromyzon marinus biology.protein lcsh:Q sense organs 030217 neurology & neurosurgery Research Article |
| Zdroj: | Royal Society Open Science Royal Society Open Science, Vol 4, Iss 7 (2017) |
| ISSN: | 2054-5703 |
| Popis: | The spectral composition of ambient light varies across both space and time. Many species of jawed vertebrates adapt to this variation by tuning the sensitivity of their photoreceptors via the expression of CYP27C1, an enzyme that converts vitamin A 1 into vitamin A 2 , thereby shifting the ratio of vitamin A 1 -based rhodopsin to red-shifted vitamin A 2 -based porphyropsin in the eye. Here, we show that the sea lamprey ( Petromyzon marinus ), a jawless vertebrate that diverged from jawed vertebrates during the Cambrian period (approx. 500 Ma), dynamically shifts its photoreceptor spectral sensitivity via vitamin A 1 -to-A 2 chromophore exchange as it transitions between photically divergent aquatic habitats. We further show that this shift correlates with high-level expression of the lamprey orthologue of CYP27C1, specifically in the retinal pigment epithelium as in jawed vertebrates. Our results suggest that the CYP27C1-mediated vitamin A 1 -to-A 2 switch is an evolutionarily ancient mechanism of sensory plasticity that appeared not long after the origin of vertebrates. |
| Databáze: | OpenAIRE |
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