Methyl inosine monophosphate: A potential immunotherapeutic for early human immunodeficiency virus (HIV) infection
| Autor: | Robert M. Nelson, Alfredo Giner-Sorolla, Elba M. Hadden, Craig Monell, Steven Specter, John W. Hadden, Joseph Ongradi, Mette Strand, Marina Sosa |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
medicine.drug_class Ratón medicine.medical_treatment Lymphocyte Indomethacin Immunology HIV Infections In Vitro Techniques Biology Immunostimulant Mice Adjuvants Immunologic Inosine Monophosphate In vivo Immunopathology medicine Animals Humans Lymphocytes Phytohemagglutinins Inosine Pharmacology Mice Inbred BALB C Chemotherapy Leukemia Experimental Immunosuppression Middle Aged Friend murine leukemia virus medicine.anatomical_structure Interleukin-2 Female medicine.drug |
| Zdroj: | International Journal of Immunopharmacology. 14:555-563 |
| ISSN: | 0192-0561 |
| DOI: | 10.1016/0192-0561(92)90116-3 |
| Popis: | MIMP is a new thymomimetic purine under development for immunorestorative therapy. Lymphocytes were obtained from eight patients with acquired immunodeficiency disease (AIDS), eight with symptomatic pre-AIDS (ARC), and 22 normal controls and were stimulated in vitro with phytohemagglutinin (PHA). AIDS patients (mean CD4 counts of 40) showed PHA responses less than 10% of control while ARC patients (mean CD4 counts of 544) showed responses approximately 50% of the control responses. MIMP (0.1, 1, 10 and 100 micrograms/ml) progressively augmented the PHA responses in all these groups. The augmentation of the responses of the leukocytes of AIDS patients while statistically significant was minimal. The augmentation of the responses of ARC patients was significant and their maximal responses approached control levels. The effect of 1 micrograms/ml MIMP was comparable with that observed with indomethacin (10(-6) M) and interleukin-2 (IL2 - 4 units/ml) and was additive with each of these stimulants. In a parallel manner, MIMP restored the suppression of control lymphocytes induced by the immunosuppressive 17 amino acid fragment of the P41 peptide of HIV. In vivo experiments showed that MIMP significantly delayed death in a murine FLV AIDS model at a dose of 1 mg/kg by the oral or parenteral route. MIMP is under preclinical development for early HIV disease to forestall progression to AIDS by attenuating virus-induced immunosuppression. |
| Databáze: | OpenAIRE |
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