MIBG scans in patients with stage 4 neuroblastoma reveal two metastatic patterns, one is associated with MYCN amplification and in MYCN-amplified tumours correlates with a better prognosis

Autor: Koos H. Zwinderman, Genevieve Laureys, Susan G. Kreissman, Ingrid Øra, Max M. van Noesel, Gertjan J.L. Kaspers, Boen L. Kam, Rogier Versteeg, Johannes H. Schulte, Berthe L. F. van Eck-Smit, Gregory A. Yanik, Barbara Hero, Godelieve A.M. Tytgat, Huib N. Caron, Bieke Lambert, Gitta Bleeker, Annelies van Schie, Matthias Schmidt
Přispěvatelé: CCA -Cancer Center Amsterdam, APH - Amsterdam Public Health, Paediatric Oncology, Other departments, Epidemiology and Data Science, Oncogenomics, Pediatrics, Radiology & Nuclear Medicine, Pediatric surgery, Radiology and nuclear medicine, CCA - Innovative therapy
Rok vydání: 2014
Předmět:
Male
Oncology
Pathology
PREDICTION
medicine.medical_treatment
Medizin
MIBG scan
CHILDREN
Metastases
Multimodal Imaging
Neuroblastoma
IV NEUROBLASTOMA
HIGH-RISK NEUROBLASTOMA
Medicine and Health Sciences
Neoplasm Metastasis
Stage (cooking)
Child
Outcome
Oncogene Proteins
N-Myc Proto-Oncogene Protein
medicine.diagnostic_test
Nuclear Proteins
General Medicine
CHEMOTHERAPY
Prognosis
3-Iodobenzylguanidine
Radiology Nuclear Medicine and imaging
Positron emission tomography
Child
Preschool
Predictive value of tests
Original Article
Female
INRG TASK-FORCE
Metastatic patterns
medicine.medical_specialty
Adolescent
chemical and pharmacologic phenomena
DIAGNOSIS
EVENT-FREE SURVIVAL
Predictive Value of Tests
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
In patient
Survival analysis
Chemotherapy
business.industry
Infant
medicine.disease
Positron-Emission Tomography
I-123 METAIODOBENZYLGUANIDINE SCINTIGRAPHY
Mycn amplification
Radiopharmaceuticals
Tomography
X-Ray Computed
FOLLOW-UP
business
Zdroj: European journal of nuclear medicine and molecular imaging, 42(2), 222-230. Springer Verlag
European Journal of Nuclear Medicine and Molecular Imaging, 42(2), 222-230. Springer-Verlag
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
European Journal of Nuclear Medicine and Molecular Imaging
Bleeker, G, Eck-Smit, B L, Zwinderman, K H, Versteeg, R, van Noesel, M M, Kam, B L, Kaspers, G J, van Schie, A, Kreissman, S G, Yanik, G, Hero, B, Schmidt, M, Laureys, G, Lambert, B, Ora, I, Schulte, J H, Caron, H N & Tytgat, G A 2015, ' MIBG scans in patients with stage 4 neuroblastoma reveal two metastatic patterns, one is associated with MYCN amplification and in MYCN-amplified tumours correlates with a better prognosis ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 42, no. 2, pp. 222-230 . https://doi.org/10.1007/s00259-014-2909-1
European Journal of Nuclear Medicine and Molecular Imaging, 42(2), 222-230. Springer Verlag
ISSN: 1619-7089
1619-7070
DOI: 10.1007/s00259-014-2909-1
Popis: Purpose The aim of this study was to find clinically relevant MIBG-avid metastatic patterns in patients with newly diagnosed stage 4 neuroblastoma. Methods Diagnostic 123I-MIBG scans from 249 patients (123 from a European and 126 from the COG cohort) were assessed for metastatic spread in 14 body segments and the form of the lesions: “focal” (clear margins distinguishable from adjacent background) or “diffuse” (indistinct margins, dispersed throughout the body segment). The total numbers of diffuse and focal lesions were recorded. Patients were then categorized as having lesions exclusively focal, lesions more focal than diffuse, lesions more diffuse than focal, or lesions exclusively diffuse. Results Diffuse lesions affected a median of seven body segments and focal lesions a median of two body segments (P
Databáze: OpenAIRE
Externí odkaz: