Electrodeposited platinum-iridium coating improves in vivo recording performance of chronically implanted microelectrode arrays
| Autor: | John J. Whalen, Chunxiu Yu, Curtis D. Lee, Warren M. Grill, Isaac R. Cassar, Artin Petrossians, Jaydeep Sambangi |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Biophysics chemistry.chemical_element Bioengineering 02 engineering and technology engineering.material Iridium Article Rats Sprague-Dawley Biomaterials 03 medical and health sciences Coated Materials Biocompatible Coating In vivo Electric Impedance Animals Single-unit recording Platinum 030304 developmental biology 0303 health sciences 021001 nanoscience & nanotechnology Electroplating Electrodes Implanted Microelectrode Electrophysiology chemistry Mechanics of Materials Electrode Ceramics and Composites engineering Female 0210 nano-technology Microelectrodes Biomedical engineering |
| Zdroj: | Biomaterials |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2019.03.017 |
| Popis: | Reliable single unit neuron recordings from chronically implanted microelectrode arrays (MEAs) are essential tools in the field of neural engineering. However, following implantation, MEAs undergo a foreign body response that functionally isolates them from the brain and reduces the useful longevity of the array. We tested a novel electrodeposited platinum-iridium coating (EPIC) on penetrating recording MEAs to determine if it improved recording performance. We chronically implanted the arrays in rats and used electrophysiological and histological measurements to compare quantitatively the single unit recording performance of coated vs. uncoated electrodes over a 12-week period. The coated electrodes had substantially lower impedance at 1 kHz and reduced noise, increased signal-to-noise ratio, and increased number of discernible units per electrode as compared to uncoated electrodes. Post-mortem immunohistochemistry showed no significant differences in the immune response between coated and uncoated electrodes. Overall, the EPIC arrays provided superior recording performance than uncoated arrays, likely due to lower electrode impedance and reduced noise. |
| Databáze: | OpenAIRE |
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