PSV-8 Glucocorticoid receptor agonist (GRA): what is the best delivery method to newly weaned pigs?

Autor:	Amanda R Rakhshandeh, Hailey Wooten, Anoosh Rakhshandeh, Hwanhee Kim
Rok vydání:	2020
Předmět:	Agonist medicine.medical_specialty medicine.drug_class business.industry General Medicine Abstracts Glucocorticoid receptor Endocrinology Internal medicine parasitic diseases Genetics medicine Animal Science and Zoology business Food Science
Zdroj:	J Anim Sci
ISSN:	1525-3163 0021-8812
DOI:	10.1093/jas/skaa054.279
Popis:	We previously found that i.m. injection of GRA, similar to in-feed antibiotics, improves measures of intestinal integrity, nutrient digestibility, and overall growth performance in nursery pigs. In addition, we have demonstrated that the mitigating effects of GRA on the stress of weaning is predominantly done by subsiding the inflammatory response that often accompanies early weaning. The objective of the current study was to explore the most practical methods for delivering GRA to newly weaned pigs. One-hundred and sixty-seven PIC pigs were weaned at 25 ±1.0 days of age (BW 7 ±1.2 kg), and assigned to fourteen treatments (3-4 pigs /pen; 3 pens/treatment). Seven treatments were tested within two sexes (gilts vs. barrows). The treatments were: 1) i.m. injection of GRA (two injections, 0.2 mg/kg BW at -1 and 3 d post-weaning), 2) two levels of in-water GRA (0.8 and 1.6 ppm), 3) in-feed GRA (2.5 and 5.0 ppm), 4) in-feed antibiotic (ANT, 100 ppm tylosin), and 5) control. Dexamethasone was used as GRA. Pigs had free access to in-feed or in-water GRA or ANT during the 1st-week post-weaning. Parameters of growth performance were measured weekly until the end of the nursery phase. A completely randomized design and repeated measurement ANOVA (PROC MIXED) in SAS were used for statistical analyses. In-water, in-feed, and i.m. GRA treatments resulted in growth performance outcomes comparable to that of in-feed ANT. Relative to CON pigs, both ANT and GRA improved ADG and G: F during the nursery phase (P < 0.05). Among the delivery methods tested, 2.5 ppm of in-feed GRA resulted in superior ADG (GRA vs. CON; 0.29 vs. 0.20 kg/d) and G: F (0.63 vs. 0.40 ± 0.05), compared to the control group (P < 0.02). Collectively, these results suggested that in-feed treatment is the best method for delivering GRA to newly weaned pigs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36d4cf56664d69ad668eac2ac00edff https://doi.org/10.1093/jas/skaa054.279 Zobrazit plný text záznamu