Polycystic ovary syndrome and the single nucleotide polymorphisms of methylenetetrahydrofolate reductase: a pilot observational study

Autor:	Julian H. Barth, Helen M. Picton, Zoe Yates, M. Palep-Singh, A.H. Balen
Rok vydání:	2007
Předmět:	Adult medicine.medical_specialty endocrine system diseases Homocysteine Genotype Single-nucleotide polymorphism Pilot Projects Polymorphism Single Nucleotide White People chemistry.chemical_compound Insulin resistance Asian People Gene Frequency Internal medicine Diabetes mellitus medicine Humans Allele Asia Southeastern Methylenetetrahydrofolate Reductase (NADPH2) biology Anthropometry business.industry Polycystic ovary syndrome (PCOS) Obstetrics and Gynecology General Medicine medicine.disease Polycystic ovary female genital diseases and pregnancy complications Endocrinology Reproductive Medicine chemistry Methylenetetrahydrofolate reductase Vitamin B Complex biology.protein Female Insulin Resistance business Polycystic Ovary Syndrome
Zdroj:	Human fertility (Cambridge, England). 10(1)
ISSN:	1464-7273
Popis:	Polycystic ovary syndrome (PCOS), insulin resistance and overall mortality due to diabetes and coronary artery disease are higher in South Asians than in Caucasians.We compared the prevalence of the C677T and A1298C single nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene in South Asian and Caucasian women, its association with folate and homocysteine (Hcy) metabolism, and its relevance to future atherogenic events.71 women were recruited for the study: South Asian PCOS (21) plus controls (9) and Caucasian PCOS (25) plus controls (16). Anthropometric and laboratory parameters were compared. South Asian PCOS women were significantly hyperandrogenic and exhibited a greater degree of insulin resistance. Caucasian PCOS women had higher plasma Hcy concentrations with a 1.9 times higher frequency of the T allele than the South Asian PCOS group. In the presence of this variant allele, plasma Hcy levels appear to be higher in both PCOS groups. The South Asians had a 1.8 times higher frequency of the C allele than the Caucasians; however, the overall frequency was comparable in the two PCOS groups. The frequency of homozygosity, i.e. TT677 and CC1298, was 7.2% and 4.9% in the Caucasians and 0% and 16.6% in the South Asian recruits, respectively. Dietary inadequacies in the South Asian women can influence their plasma folate and B12 concentrations resulting in hyperhomocysteinemia which, in combination with dyslipidaemia and insulin resistance, can lead to long-term atherogenic consequences.Current data suggests that the mechanisms of atherothrombosis have separate pathways in the two ethnic groups. Larger studies exploring the current theme need to be carried out in the PCOS groups to obtain adequate insight.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36a82e7cd0e686154e4eb5baf1c9e55 https://pubmed.ncbi.nlm.nih.gov/17454207 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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