Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes

Autor: Michelangela Barbieri, Raffaele Marfella, Pasquale Paolisso, Giuseppe Paolisso, Celestino Sardu, Maria Rosaria Rizzo
Přispěvatelé: Sardu, Celestino, Barbieri, Michelangela, Rizzo, Maria Rosaria, Paolisso, Pasquale, Paolisso, Giuseppe, Marfella, Raffaele
Jazyk: angličtina
Rok vydání: 2015
Předmět:
medicine.medical_specialty
endocrine system diseases
Cardiac fibrosis
medicine.medical_treatment
Endocrinology
Diabetes and Metabolism
Population
Cardiac resynchronization therapy
Review Article
030204 cardiovascular system & hematology
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Cardiac Resynchronization Therapy
03 medical and health sciences
0302 clinical medicine
Endocrinology
Quality of life
Internal medicine
medicine
Humans
cardiovascular diseases
education
Heart Failure
education.field_of_study
Ejection fraction
lcsh:RC648-665
business.industry
Type 2 Diabetes Mellitus
medicine.disease
Prognosis
MicroRNAs
medicine.anatomical_structure
Treatment Outcome
Diabetes Mellitus
Type 2
Ventricle
030220 oncology & carcinogenesis
Heart failure
Cardiology
cardiovascular system
business
Zdroj: Journal of Diabetes Research
Journal of Diabetes Research, Vol 2016 (2016)
ISSN: 2314-6753
2314-6745
Popis: Heart failure (HF) and type 2 diabetes mellitus (T2DM) are two growing and related diseases in general population and particularly in elderly people. In selected patients affected by HF and severe dysfunction of left ventricle ejection fraction (LVEF), with left bundle brunch block, the cardiac resynchronization therapy with a defibrillator (CRT) is the treatment of choice to improve symptoms, NYHA class, and quality of life. CRT effects are related to alterations in genes and microRNAs (miRs) expression, which regulate cardiac processes involved in cardiac apoptosis, cardiac fibrosis, cardiac hypertrophy and angiogenesis, and membrane channel ionic currents. Different studies have shown a different prognosis in T2DM patients and T2DM elderly patients treated by CRT-D. We reviewed the literature data on CRT-D effect on adult and elderly patients with T2DM as compared with nondiabetic patients.
Databáze: OpenAIRE
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