Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes
Autor: | Michelangela Barbieri, Raffaele Marfella, Pasquale Paolisso, Giuseppe Paolisso, Celestino Sardu, Maria Rosaria Rizzo |
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Přispěvatelé: | Sardu, Celestino, Barbieri, Michelangela, Rizzo, Maria Rosaria, Paolisso, Pasquale, Paolisso, Giuseppe, Marfella, Raffaele |
Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
medicine.medical_specialty
endocrine system diseases Cardiac fibrosis medicine.medical_treatment Endocrinology Diabetes and Metabolism Population Cardiac resynchronization therapy Review Article 030204 cardiovascular system & hematology lcsh:Diseases of the endocrine glands. Clinical endocrinology Cardiac Resynchronization Therapy 03 medical and health sciences 0302 clinical medicine Endocrinology Quality of life Internal medicine medicine Humans cardiovascular diseases education Heart Failure education.field_of_study Ejection fraction lcsh:RC648-665 business.industry Type 2 Diabetes Mellitus medicine.disease Prognosis MicroRNAs medicine.anatomical_structure Treatment Outcome Diabetes Mellitus Type 2 Ventricle 030220 oncology & carcinogenesis Heart failure Cardiology cardiovascular system business |
Zdroj: | Journal of Diabetes Research Journal of Diabetes Research, Vol 2016 (2016) |
ISSN: | 2314-6753 2314-6745 |
Popis: | Heart failure (HF) and type 2 diabetes mellitus (T2DM) are two growing and related diseases in general population and particularly in elderly people. In selected patients affected by HF and severe dysfunction of left ventricle ejection fraction (LVEF), with left bundle brunch block, the cardiac resynchronization therapy with a defibrillator (CRT) is the treatment of choice to improve symptoms, NYHA class, and quality of life. CRT effects are related to alterations in genes and microRNAs (miRs) expression, which regulate cardiac processes involved in cardiac apoptosis, cardiac fibrosis, cardiac hypertrophy and angiogenesis, and membrane channel ionic currents. Different studies have shown a different prognosis in T2DM patients and T2DM elderly patients treated by CRT-D. We reviewed the literature data on CRT-D effect on adult and elderly patients with T2DM as compared with nondiabetic patients. |
Databáze: | OpenAIRE |
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