Transcription Profiles of the Ductus Arteriosus in Brown-Norway Rats With Irregular Elastic Fiber Formation
| Autor: | Yi Ting Hsieh, Norika Mengchia Liu, Toru Akaike, Eriko Ohmori, Nobuhito Goda, Susumu Minamisawa, Ichige Kajimura, Toshio Ohshima, Tomohiro Yokota |
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| Rok vydání: | 2014 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Candidate gene Transcription Genetic TBX20 Quantitative Trait Loci Muscle Proteins Quantitative trait locus SCN3B Ductus arteriosus Animals Medicine Ductus Arteriosus Patent Gene business.industry Ductus Arteriosus General Medicine Anatomy Elastic Tissue Chromosomes Mammalian Molecular biology Phenotype Rats Inbred F344 Rats medicine.anatomical_structure Animals Newborn Gene Expression Regulation DNA microarray Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation Journal. 78:1224-1233 |
| ISSN: | 1347-4820 1346-9843 |
| Popis: | BACKGROUND Patent ductus arteriosus (PDA) is one of the most common congenital cardiovascular defects in children. The Brown-Norway (BN) inbred rat presents a higher frequency of PDA. A previous study reported that 2 different quantitative trait loci on chromosomes 8 and 9 were significantly linked to PDA in this strain. Nevertheless, the genetic or molecular mechanisms underlying PDA phenotypes in BN rats have not been fully investigated yet. METHODS AND RESULTS It was found that the elastic fibers were abundant in the subendothelial area but scarce in the media even in the closed ductus arteriosus (DA) of full-term BN neonates. DNA microarray analysis identified 52 upregulated genes (fold difference >2.5) and 23 downregulated genes (fold difference |
| Databáze: | OpenAIRE |
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