OGP: A Repository of Experimentally Characterized O-glycoproteins to Facilitate Studies on O-glycosylation
| Autor: | Huang, Jiang-Ming, Wu, Meng-Xi, Zhang, Yang, Kong, Si-Yuan, Liu, Ming-Qi, Jiang, Bi-Yun, Yang, Peng-Yuan, Cao, Wei-Qian |
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| Rok vydání: | 2021 |
| Předmět: |
Glycan
Glycosylation Computer science Data submission Biochemistry chemistry.chemical_compound 03 medical and health sciences 0302 clinical medicine Genetics Database search engine Statistical analysis Databases Protein Molecular Biology Glycoproteins 030304 developmental biology chemistry.chemical_classification 0303 health sciences Information retrieval biology Accession number (library science) carbohydrates (lipids) Computational Mathematics chemistry biology.protein Experimental methods Glycoprotein 030217 neurology & neurosurgery |
| Zdroj: | Genomics, Proteomics & Bioinformatics. 19:611-618 |
| ISSN: | 1672-0229 |
| DOI: | 10.1016/j.gpb.2020.05.003 |
| Popis: | Numerous studies on cancer, biopharmaceuticals, and clinical trials have necessitated comprehensive and precise analysis of protein O-glycosylation. However, the lack of updated and convenient databases deters the storage and utilization of emerging O-glycoprotein data. To resolve this issue, an O-glycoprotein repository named OGP was established in this work. It was constructed with a collection of O-glycoprotein data from different sources. OGP contains 9354 O-glycosylation sites and 11,633 site-specific O-glycans mapping to 2133 O-glycoproteins, and it is the largest O-glycoprotein repository thus far. Based on the recorded O-glycosites, an O-glycosylation site prediction tool was developed. Moreover, an OGP-backed website is already available (http://www.oglyp.org/). The website comprises four specially designed and user-friendly modules: Statistic Analysis, Database Search, Site Prediction, and Data Submit. The first version of OGP repository and the website allow users to obtain vast O-glycoprotein related information, such as protein accession numbers, glycopeptides, site-specific glycan structures, experimental methods, and potential glycosylation sites. O-glycosylation data mining can be performed efficiently on this website, which can greatly facilitates O-glycosylation studies. |
| Databáze: | OpenAIRE |
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