Effects of prenatal immune activation on amphetamine-induced addictive behaviors: Contributions from animal models
| Autor: | R. Wuo-Silva, Luciana T.C. Ribeiro, Camilla L. Patti, Karina A. Zanin, Leonardo B. Lopes-Silva, Aline R. Borçoi, Roberto Frussa-Filho, Stephanie B. Grapiglia, A.W. Hollais, L.M.B. Ceccon, Renan Santos-Baldaia, Laís F. Berro |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Offspring media_common.quotation_subject Amphetamine-Related Disorders Motor Activity Affect (psychology) Mice Cocaine Pregnancy Internal medicine Conditioning Psychological medicine Animals Amphetamine Biological Psychiatry media_common Pharmacology Addiction medicine.disease Comorbidity Conditioned place preference Disease Models Animal Poly I-C Endocrinology Schizophrenia Prenatal Exposure Delayed Effects Anesthesia Exploratory Behavior Female Stereotyped Behavior Psychology medicine.drug |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 63:63-69 |
| ISSN: | 0278-5846 |
| Popis: | Background Prenatal environmental adversities may affect brain development and are associated with increased risk for schizophrenia, an illness with 50% comorbidity with addiction. Maternal immune activation by poly-inosinic–citidilic acid (Poly(I:C)) exposure can promote behavioral alterations consistent with schizophrenia symptoms in rodents. Objectives Considering the vulnerability to addiction in patients with schizophrenia, we evaluated the interactions between prenatal Poly(I:C) administration and addiction in two animal models (behavioral sensitization and conditioned place preference — CPP) in mice repeatedly treated with amphetamine (AMP). Additionally, stereotyped behavior and cross-sensitization with cocaine (COC) were also investigated. Methods Swiss male mice offspring were submitted to prenatal administration of 5 mg/kg Poly(I:C) in the 9th day of pregnancy. At the age of 90 days, mice were treated with 2.5 mg/kg AMP for 9 days to evaluate behavioral sensitization or stereotyped behavior. Cross-sensitization with 10 mg/kg COC was evaluated 24 h after the last treatment day. For AMP-induced CPP evaluation, mice were treated during 8 consecutive days. Results Prenatal Poly(I:C) administration potentiated both AMP-induced behavioral sensitization and CPP. Furthermore, Poly(I:C) increased cross-sensitization with COC. Conclusions Prenatal administration of Poly(I:C) is able to potentiate vulnerability to addiction in two animal models, without however modulating stereotyped behavior. |
| Databáze: | OpenAIRE |
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