Delineation of an oral cancer lesion with swept-source optical coherence tomography
| Autor: | Chi-Chung Yang, Cheng-Kuan Lee, Chun-Ping Chiang, Chih-Wei Lu, Meng-Tsan Tsai, Yih-Ming Wang, Hsiang-Chieh Lee |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Biomedical Engineering
Signal Sensitivity and Specificity Standard deviation Pattern Recognition Automated Biomaterials Lesion Optics Optical coherence tomography Artificial Intelligence Image Interpretation Computer-Assisted medicine Humans Detection theory Optical tomography Exponential decay Physics medicine.diagnostic_test business.industry Reproducibility of Results Image Enhancement Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials Mouth Neoplasms medicine.symptom business Sensitivity (electronics) Algorithms Tomography Optical Coherence |
| Zdroj: | Journal of biomedical optics. 13(4) |
| ISSN: | 1083-3668 |
| Popis: | We demonstrate the ex vivo imaging of an oral cancerous sample with a swept-source optical coherence tomography (SS-OCT) system. With the axial resolution of 8 microm in free space and system sensitivity of 108 dB, we can well distinguish the normal and abnormal tissue portions in a sample. In particular, we analyze the lateral variation of A-scan profiles to show two parameters of SS-OCT signal for delineating an oral cancer lesion. One of the parameters is the decay constant in the exponential fitting of the SS-OCT signal intensity along depth. This decay constant decreases as the A-scan point moves laterally across the margin of a lesion. The other parameter is the standard deviation of the SS-OCT signal intensity fluctuation in an A-scan. This parameter increases significantly when the A-scan point is moved across the transition region between the normal and abnormal portions. Such parameters are useful for determining the margins of oral cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|