Correlated activity of cortical neurons survives extensive removal of feedforward sensory input
| Autor: | Katharine A Shapcott, David A. Leopold, Alexander Maier, Michael C. Schmid, Richard C. Saunders, Joscha T. Schmiedt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Stimulus (physiology) Macaque Article Lesion Correlation 03 medical and health sciences 0302 clinical medicine biology.animal medicine Premovement neuronal activity Animals ddc:610 Visual Cortex Neurons Multidisciplinary biology business.industry Feed forward Cortical neurons Macaca mulatta Neurophysiological Monitoring 030104 developmental biology Visual cortex medicine.anatomical_structure Female Artificial intelligence medicine.symptom business Neuroscience 030217 neurology & neurosurgery Photic Stimulation |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep34886 |
| Popis: | A fundamental property of brain function is that the spiking activity of cortical neurons is variable and that some of this variability is correlated between neurons. Correlated activity not due to the stimulus arises from shared input but the neuronal circuit mechanisms that result in these noise correlations are not fully understood. Here we tested in the visual system if correlated variability in mid-level area V4 of visual cortex is altered following extensive lesions of primary visual cortex (V1). To this end we recorded longitudinally the neuronal correlations in area V4 of two behaving macaque monkeys before and after a V1 lesion while the monkeys fixated a grey screen. We found that the correlations of neuronal activity survived the lesions in both monkeys. In one monkey, the correlation of multi-unit spiking signals was strongly increased in the first week post-lesion, while in the second monkey, correlated activity was slightly increased, but not greater than some week-by-week fluctuations observed. The typical drop-off of inter-neuronal correlations with cortical distance was preserved after the lesion. Therefore, as V4 noise correlations remain without feedforward input from V1, these results suggest instead that local and/or feedback input seem to be necessary for correlated activity. |
| Databáze: | OpenAIRE |
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