The optical coherence tomography angiography findings of rheumatoid arthritis patients taking hydroxychloroquine
| Autor: | Mehmet Resid Onen, Ozlem Evren Kemer, Emine Esra Karaca, Ahmet Omma, Dilay Ozek, Cigdem Coskun |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Visual Acuity Retina Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Vessel density Retinal Diseases Humans Medicine In patient Fluorescein Angiography Retrospective Studies medicine.diagnostic_test business.industry Retinal Vessels Hydroxychloroquine General Medicine Optical coherence tomography angiography Middle Aged medicine.disease Retinal vessel Ophthalmology Antirheumatic Agents Case-Control Studies Rheumatoid arthritis Angiography 030221 ophthalmology & optometry Visual Field Tests Female Radiology Visual Fields business Tomography Optical Coherence 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European Journal of Ophthalmology. 29:532-537 |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.1177/1120672118801125 |
| Popis: | Purpose: The aim of this study is to measure retinal vessel density and thickness of the macula by optical coherence tomography angiography in patients with rheumatoid arthritis taking hydroxychloroquine. Methods: The study included 40 patients with rheumatoid arthritis taking hydroxychloroquine and 20 age-, gender-, and axial length-matched control subjects. Patients were divided into two groups according to the duration of hydroxychloroquine use. Twenty four of the patients were taking hydroxychloroquine for more than 5 years (Group 1), and the rest of 16 were taking hydroxychloroquine for less than 5 years (Group 2). A total of 20 age- and gender-matched volunteers with similar axial length were selected as Group 3. All of the patients underwent optical coherence tomography angiography, and 3 mm × 3 mm scanning mode was chosen for analyzing vascular density and morphological characteristics on the choriocapillaris layer. In addition, Humphrey visual field 10–2 was evaluated in each subject. Results: The temporal deep vascular density was measured as 48.13% ± 8.5% in Group 1, 54.42% ± 10.3% in Group 2, and 60.35% ± 13.1% in Group 3. Deep temporal and deep hemi-inferior vascular density was significantly lower in Group 1 in comparison with Group 3 (p = 0.041 and p = 0.046, respectively). Visual field testing was normal in all patients. Conclusion: The optical coherence tomography angiography findings showed that the parafoveal deep temporal and deep hemi-inferior vascular plexus density was reduced in patients taking hydroxychloroquine for more than 5 years despite having normal perimetry. This observation, which can be obtained only through optical coherence tomography angiography, may be relevant to the early findings of hydroxychloroquine toxicity. |
| Databáze: | OpenAIRE |
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