Reduced left atrial function on exercise in patients with heart failure and normal ejection fraction
| Autor: | G. Heatlie, Francisco Leyva, P Nightingale, Eveline Lee, John E. Sanderson, Y. T. Tan, F. Wenzelburger |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Heart disease Diastole Physical exercise Exercise intolerance Asymptomatic Tissue Doppler echocardiography Internal medicine medicine Humans Aged Ultrasonography Heart Failure Diastolic Exercise Tolerance Ejection fraction business.industry Stroke Volume medicine.disease Respiratory Function Tests Dyspnea Case-Control Studies Heart failure Hypertension Cardiology Atrial Function Left Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Heart. 96:1017-1023 |
| ISSN: | 1355-6037 |
| DOI: | 10.1136/hrt.2009.189118 |
| Popis: | The cardinal symptom of heart failure with a normal ejection fraction (HFNEF) is exertional dyspnoea. The authors hypothesised that failure of left atrial (LA) compensatory mechanism particularly on exercise contributes to the genesis of symptoms in HFNEF patients.Fifty HFNEF patients, 15 asymptomatic hypertensive subjects and 30 healthy controls underwent rest and submaximal exercise echocardiography. Rest and exercise systolic, early diastolic and late diastolic (Am) mitral annular velocities were assessed using colour tissue Doppler echocardiography. Left atrial functional reserve index was calculated. Am at rest was comparable between all three groups, but exercise Am was significantly lower in HFNEF compared with hypertensive subjects and healthy controls resulting in a lower LA functional reserve index (0.84 (1.34) vs 2.39 (1.27) and 1.81 (1.39), p0.001). LA volume index was significantly higher in HFNEF patients (30.4 (9.2) vs 27.9 (6.3) and 23.2 (7.1) ml/m(2), p=0.002). There was a significant correlation between Am on exercise with peak VO(2) max (r=0.514, p0.001) and E/Em on exercise (r=-0.547, p0.001). Area under the receiver operating characteristic for Am on exercise was 0.768 (95% CI=0.660 to 0.877).HFNEF patients have reduced LA function on exercise in addition to left ventricular systolic and diastolic dysfunctions. Reduced LA function probably contributes significantly to exercise intolerance and breathlessness in HFNEF patients. |
| Databáze: | OpenAIRE |
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