Circulating Tumor Cells in Colorectal Cancer: Detection Systems and Clinical Utility
| Autor: | József Petrik, Donatella Verbanac, Marija Fabijanec, Andrea Hulina-Tomašković, Andrea Čeri, Anita Somborac-Bačura, Roberta Petlevski, Marija Grdić Rajković, Lada Rumora, Božo Krušlin, Mario Štefanović, Neven Ljubičić, Neven Baršić, Antonija Hanžek, Luka Bočkor, Ivana Ćelap, Alma Demirović, Karmela Barišić |
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| Rok vydání: | 2022 |
| Předmět: |
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences
liquid biopsy BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti Organic Chemistry clinical utility colorectal cancer Cell Count General Medicine circulating tumor cells Neoplastic Cells Circulating Catalysis Computer Science Applications Inorganic Chemistry viable CTCs isolation techniques Biomarkers Tumor Humans CTC clusters detection methods Physical and Theoretical Chemistry Colorectal Neoplasms Molecular Biology Spectroscopy |
| Zdroj: | International Journal of Molecular Sciences Volume 23 Issue 21 |
| ISSN: | 1422-0067 |
| Popis: | Colorectal cancer (CRC) is the third most common cancer worldwide. The high mortality from CRC is mainly related to metastasis affecting distant organs and their function. Dissemination of tumor cells from the primary tumor and hematogeneous spread are considered crucial in the formation of tumor metastases. The analysis of circulating tumor cells (CTCs) and CTC clusters in the blood can be used for the early detection of invasive cancer. Moreover, CTCs have a prognostic significance in the monitoring of a malignant disease or the response to chemotherapy. This work presents an overview of the research conducted on CTCs with the aim of finding suitable detection systems and assessing the possibility of clinical applications in patients with CRC. |
| Databáze: | OpenAIRE |
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