HLA-A, -B, -C, -DQB1, and -DRB1,3,4,5 allele and haplotype frequencies in the Costa Rica Central Valley Population and its relationship to worldwide populations
| Autor: | Willem Buján-Boza, A.J. McWhinnie, Michael A. Hoddinott, Anila Shah, Esteban Arrieta-Bolaños, Lizbeth Salazar-Sánchez, Oana Dimitriu, J. Alejandro Madrigal, AM Little, Wilbert Alfaro-Bourrouet, Finnuala Fowles, Priscilla Órlich-Pérez, H Maldonado-Torres |
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| Rok vydání: | 2011 |
| Předmět: |
Costa Rica
Immunology Population Human leukocyte antigen Ethnic origin Biology Linkage Disequilibrium Gene Frequency Population Groups Genotype Cluster Analysis Humans Immunology and Allergy Allele education Genetic association Genetics Analysis of Variance education.field_of_study Histocompatibility Testing Histocompatibility Antigens Class I Haplotype Histocompatibility Antigens Class II General Medicine HLA-A Haplotypes |
| Zdroj: | Human Immunology. 72:80-86 |
| ISSN: | 0198-8859 |
| Popis: | The human leukocyte antigen (HLA) system is the most polymorphic in humans. Its allele, genotype, and haplotype frequencies vary significantly among different populations. Molecular typing data on HLA are necessary for the development of stem cell donor registries, cord blood banks, HLA-disease association studies, and anthropology studies. The Costa Rica Central Valley Population (CCVP) is the major population in this country. No previous study has characterized HLA frequencies in this population. Allele group and haplotype frequencies of HLA genes in the CCVP were determined by means of molecular typing in a sample of 130 unrelated blood donors from one of the country's major hospitals. A comparison between these frequencies and those of 126 populations worldwide was also carried out. A minimum variance dendrogram based on squared Euclidean distances was constructed to assess the relationship between the CCVP sample and populations from all over the world. Allele group and haplotype frequencies observed in this study are consistent with a profile of a dynamic and diverse population, with a hybrid ethnic origin, predominantly Caucasian-Amerindian. Results showed that populations genetically closest to the CCVP are a Mestizo urban population from Venezuela, and another one from Guadalajara, Mexico. |
| Databáze: | OpenAIRE |
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