Intraventricular administration of morphine for control of intractable cancer pain in 90 patients
| Autor: | George Foroglou, Panagiotis Selviaridis, George Fountzilas, Antonios Karavelis |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Side effect Nausea Drug Administration Schedule Neoplasms medicine Ommaya reservoir Humans Aged Injections Intraventricular Pain Measurement Aged 80 and over Dose-Response Relationship Drug Morphine business.industry Infusion Pumps Implantable Middle Aged Surgery Pain Intractable Analgesics Opioid Opioid Anesthesia Vomiting Quality of Life Intractable pain Female Neurology (clinical) medicine.symptom Cancer pain business medicine.drug |
| Zdroj: | Neurosurgery. 39(1) |
| ISSN: | 0148-396X |
| Popis: | OBJECTIVE : To quantitate the relief of intractable cancer pain by the use of intraventricular morphine administration. METHODS : Intraventricular morphine administration was performed through an Ommaya reservoir. An initial dose of 0.25 mg of morphine sulfate per 24 hours was administered to all of the patients. This dose was progressively increased in 0.25-mg increments until optimal analgesia was attained. RESULTS : Sixty men and 30 women with a median age of 58 years (range, 23-80 yr) entered the study. The median duration of pain was 6 months (range, 0.5-120 mo). A daily morphine dose of up to 1 mg was adequate to achieve an analgesic effect in 77% of the patients. Only nine patients (10%) achieved < 50% pain relief. Using a multiple regression analysis, only the morphine dosage was found to be an independent prognostic factor. The most frequent side effect (22%) was nausea/vomiting. Also, there were two patients with opioid intolerance and two with intracerebral hematomas. Three reservoirs failed. CONCLUSION : Intraventricular morphine administration is a useful method for palliation of intractable cancer pain. |
| Databáze: | OpenAIRE |
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