Inhibition of Muscimol on Morphine-Induced Hyperactivity, Reverse Tolerance and Postsynaptic Dopamine Receptor Supersensitivity
| Autor: | Hack-Seang Kim, In-Seup Yoon, Ki-Wan Oh, Jin-Tae Hong, Myung Koo Lee |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Narcotics Single administration Hyperkinesis Pharmacology Receptors Dopamine Mice chemistry.chemical_compound Dopamine receptor D1 Postsynaptic potential Dopamine receptor D2 medicine Animals GABA Agonists Mice Inbred ICR Behavior Animal Morphine Muscimol Drug Tolerance General Medicine Receptors GABA-A chemistry Dopamine receptor Reverse tolerance medicine.drug |
| Zdroj: | Pharmacology. 65:204-209 |
| ISSN: | 1423-0313 0031-7012 |
| Popis: | This study was performed to investigate the effect of muscimol on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice. A single administration of morphine induced hyperactivity as measured in mice, and the morphine-induced hyperactivity was inhibited dose-dependently by the administration of the GABAA agonist, muscimol (0.3, 0.5 and 1.0 mg kg–1 i.p.). However, daily repeated administration of morphine caused the development of reverse tolerance against morphine hyperactivity (10 mg kg–1 s.c.). The administration of muscimol inhibited the development of reverse tolerance against morphine hyperactivity (10 mg kg–1 s.c.) in mice that had received chronic administration of morphine. Postsynaptic dopamine receptor supersensitivity, as shown by the enhanced ambulatory activity after administration of apomorphine (2 mg kg–1 s.c.), also developed in reverse-tolerant mice. Muscimol also inhibited the development of postsynaptic dopamine receptor supersensitivity induced by the chronic administration of morphine. These results suggest that the hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity induced by morphine can be inhibited via the activation of GABAA receptors. |
| Databáze: | OpenAIRE |
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