Constituents and Anti-Multidrug Resistance Activity of Taiwanofungus camphoratus on Human Cervical Cancer Cells

Autor: Jun Weil Liang, Tian Shung Wu, Hsin Yi Hung, Chin Fu Chen, Po Chuen Shieh, Chin-Chuan Hung, Ping Chung Kuo, Hung-Yi Chen
Rok vydání: 2019
Předmět:
0106 biological sciences
Vincristine
P-gp inhibitor
Pharmaceutical Science
Antineoplastic Agents
Drug resistance
Pharmacology
01 natural sciences
Article
Analytical Chemistry
lcsh:QD241-441
03 medical and health sciences
chemistry.chemical_compound
lcsh:Organic chemistry
Taiwanofungus camphoratus
010608 biotechnology
zhankuic acid
Drug Discovery
medicine
Humans
Doxorubicin
ATP Binding Cassette Transporter
Subfamily B
Member 1
Physical and Theoretical Chemistry
IC50
030304 developmental biology
Biological Products
0303 health sciences
Molecular Structure
chemoreversing agent
biology
Basidiomycota
Organic Chemistry
biology.organism_classification
Drug Resistance
Multiple
Multiple drug resistance
Paclitaxel
chemistry
Drug Resistance
Neoplasm
Chemistry (miscellaneous)
Molecular Medicine
Female
Efflux
HeLa Cells
medicine.drug
Zdroj: Molecules
Volume 24
Issue 20
Molecules, Vol 24, Iss 20, p 3730 (2019)
ISSN: 1420-3049
DOI: 10.3390/molecules24203730
Popis: Resistance to anti-cancer drugs is one of the main factors of treatment failure resulting in high morbidity. Among the reasons of resistance, overexpression of efflux pumps leading to multidrug resistance is an important issue that needs to be solved. Taiwanofungus camphoratus has been used as a nutritional supplement to treat various cancers. However, its effects on the resistance to chemotherapeutic agents are still unknown. In this study, we report four new chemical constituents of T. camphoratus isolated from an ether extract: camphoratins K (1) and N (2) and benzocamphorins G (3) and I (4). Furthermore, we evaluated zhankuic acids A&ndash
C for their P-glycoprotein (P-gp) inhibitory effects. The results showed that zhankuic acid A was the most potent P-gp inhibitor compound and (at 20 &mu
M) could reverse drug resistance in human cancer cells, restoring an IC50 of 78.5 nM for doxorubicin, of 48.5 nM for paclitaxel, and of 321.5 nM for vincristine, indicating a reversal fold of 48, 38, and 45 times, respectively. This study provides support for the use of T. camphoratus in the further development of cancer therapy.
Databáze: OpenAIRE
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