COMPARISON OF THE UROPROTECTIVE EFFICACY OF MESNA AND HBO TREATMENTS IN CYCLOPHOSPHAMIDE-INDUCED HEMORRHAGIC CYSTITIS

Autor:	Ahmet Tomur, Mesut Pekcan, İlksin Pişkin, Salih Deveci, Ozdal Etlik
Rok vydání:	1997
Předmět:	Male Hyperbaric Oxygenation Cyclophosphamide business.industry Urology Hyperbaric oxygenation Guinea Pigs Hemorrhage Oxygenation medicine.disease Animal model Anesthesia Cystitis medicine Animals business Mesna medicine.drug Hemorrhagic cystitis
Zdroj:	Journal of Urology. 158:2296-2299
ISSN:	1527-3792 0022-5347
DOI:	10.1016/s0022-5347(01)68238-7
Popis:	The aim of this research was to compare the protective effects of mesna, hyperbaric oxygenation (HBO), and their combination in cyclophosphamide-induced hemorrhagic cystitis in guinea pigs. Following one dose of i.p. 21.5 mg./kg. mesna administration 20 minutes before i.p. 68.1 mg./kg. cyclophosphamide, 3 additional doses of mesna were given every three hours. A total of 8 HBO exposures, 5 of which were applied prophylactically before cyclophosphamide, were performed at 2.8 ATA for 90 minutes 2 times a day. Although mesna or HBO provided significant protection for cyclophosphamide-cystitis in animal bladders, there was also significant damage compared with controls. The combination of mesna and HBO, which act through independent mechanisms, resulted in complete protection, since mean histological scores and hematuria levels in this group were not different from controls (p >0.05). Therefore, this combination may be a useful tool in the prophylaxis and treatment of cyclophosphamide-induced hemorrhagic cystitis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d356ebee7ee9c779ff540f574f2634e3 https://doi.org/10.1016/s0022-5347(01)68238-7 Zobrazit plný text záznamu