Carcinogenesis and mutagenesis by N-nitroso compounds having a basic center
| Autor: | William Lijinsky, J.E. Saavedra, Robert M. Kovatch |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Salmonella typhimurium Cancer Research medicine.medical_specialty Esophageal Neoplasms Carcinogenicity Tests Mammary gland Uterus Administration Oral Hamster Mucous membrane of nose Nitrosourea Compounds Methylamines Structure-Activity Relationship chemistry.chemical_compound Cricetinae Internal medicine Ethylamines medicine Animals Carcinogen Mesocricetus Molecular Structure biology Mutagenicity Tests business.industry Rats Inbred Strains Neoplasms Experimental biology.organism_classification Rats Inbred F344 Rats medicine.anatomical_structure Endocrinology Oncology chemistry Nitrosamine Toxicity Carcinogens Female Indicators and Reagents business Mutagens Nitroso Compounds |
| Zdroj: | Cancer Letters. 63:101-107 |
| ISSN: | 0304-3835 |
| Popis: | Two N-nitroso compounds that are derivatives of N,N-dimethylethylenediamine and are therefore strongly basic, were tested for carcinogenic activity. They were methylnitrosamino-N,N-dimethylethylamine (MNDMEA) and N,N-dimethylaminoethylnitrosoethylurea (DMENEU). Each was administered orally to male and female F344 rats by gavage. MNDMEA was also given by gavage to Syrian hamsters and to rats as a solution in drinking water. The response of rats treated with MNDMEA was almost the same by the two modes of treatment and all developed tumors of the esophagus and died in less than 40 weeks; many also had tumors of the nasal mucosa. Hamsters were less susceptible to the nitrosamine than rats, since they survived longer following a larger dose and the tumor incidence was small; several hamsters had tumors of the nasal mucosa, some males also had tumors of the liver and lung and one male and two females had a tumor of the colon. Although it is a strong directly acting mutagen, dimethylaminoethylnitrosoethylurea was weakly carcinogenic in rats, giving rise to tumors of the uterus and mammary gland in females, but having no particular target organ in male rats. The presence of a basic center in these N-nitroso compounds does not prevent their absorption nor their entry into cells, which they can transform to tumors. |
| Databáze: | OpenAIRE |
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