Influence of intimal Chlamydophila pneumoniae persistence on cardiovascular complications after coronary intervention
| Autor: | Izabela Tuleta, Georg Nickenig, René Andrié, P. Braun, D. Reek, G. Bauriedel, Dirk Skowasch |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Microbiology (medical) medicine.medical_specialty Inflammation Coronary Artery Disease Systemic inflammation medicine.disease_cause Mitochondrial Proteins Coronary artery disease Bacterial Proteins Restenosis Internal medicine medicine Humans cardiovascular diseases Chlamydophila Infections Aged business.industry Chaperonin 60 General Medicine Chlamydophila pneumoniae Middle Aged medicine.disease Antibodies Bacterial Coronary Vessels Immunohistochemistry Plaque Atherosclerotic C-Reactive Protein Infectious Diseases Atheroma Cardiology Female medicine.symptom business Mace |
| Zdroj: | Infection. 43:51-57 |
| ISSN: | 1439-0973 0300-8126 |
| DOI: | 10.1007/s15010-014-0694-1 |
| Popis: | Chlamydophila pneumoniae has been implicated in atherosclerosis/restenosis; however, clear evidence is missing. Therefore, the aim of our study was to examine the influence of intimal infection and systemic inflammation on cardiovascular complications after coronary intervention. 45 atheroma specimens from patients with symptomatic coronary artery disease who underwent directional endatherectomy with stent implantation were analyzed by immunohistochemistry to detect chlamydial (c) and human (h) heat shock protein (HSP) 60. The antibodies used against cHSP60 and hHSP60 were characterized by specificity and lack of cross immunoreactivity. In addition, serum Ig antibodies against Chlamydophila pneumoniae and against mycobacterial (m) HSP65 as well as serum CRP levels were measured. At follow-up of 6 months, quantitative coronary angiography was performed and major adverse cardiac events (MACE) were assessed. Atheroma specimens of all 10 patients with MACE were positive for cHSP60 with overall higher cHSP60 tissue expressions (1.1 ± 0.4 %) and serum CRP levels (2.18 ± 0.85 mg/dl) compared to the remaining 35 patients without MACE (7 of 35 specimens positive for cHSP60, mean cHSP60 expression: 0.4 ± 0.1 %, CRP levels: 0.67 ± 0.16 mg/dl, p |
| Databáze: | OpenAIRE |
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