Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children
| Autor: | Marina Adel Shehata, Dina Ossama Alshareif, Parveez Ahamed AbdulAzees, Patrícia Paula de Carvalho Sampaio Lima, Azadeh Abdollahi, Bennett T. Amaechi, Veronica Evans, Parisa Samadi Kalkhorani |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
business.product_category Dentistry Article Lesion 03 medical and health sciences chemistry.chemical_compound Paediatric dentistry 0302 clinical medicine Fluoride toothpaste medicine Oral diseases General Dentistry Remineralisation Toothpaste Enamel paint Chemistry business.industry 030206 dentistry Crossover study lcsh:RK1-715 Demineralization 030104 developmental biology lcsh:Dentistry visual_art visual_art.visual_art_medium medicine.symptom business Fluoride |
| Zdroj: | BDJ Open, Vol 5, Iss 1, Pp 1-9 (2019) BDJ Open |
| ISSN: | 2056-807X |
| DOI: | 10.1038/s41405-019-0026-8 |
| Popis: | Objective This in situ study compared the effectiveness of two toothpastes containing hydroxyapatite or 500 ppm fluoride in promoting remineralization and inhibiting caries development. Materials and methods Two enamel blocks (human primary teeth), one sound and one with artificially-produced caries lesion, were exposed to toothpaste containing either 10% hydroxyapatite or 500 ppm F− (amine fluoride) via intra-oral appliance worn by 30 adults in two-arm double blind randomized crossover study lasting 14 days per arm (ClinicalTrials.gov: NCT03681340). Baseline and post-test mineral loss and lesion depth (LD) were quantified using microradiography. One-sided t-test of one group mean was used for intragroup comparison (baseline vs. post-test), while two-sided t-test of two independent means was used to compare the two toothpaste groups. Results Pairwise comparison (baseline vs. test) indicated significant (p − induced lesion surface lamination, HAP produced a more homogenous lesion remineralization. Conclusions 10% hydroxyapatite achieved comparable efficacy with 500 ppm F− in remineralizing initial caries and preventing demineralization. Thus the HAP toothpaste is confirmed to be equal to the fluoride toothpaste in this study. |
| Databáze: | OpenAIRE |
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