Soluble interleukin 6 receptor levels are associated with reduced myocardial reperfusion after percutaneous coronary intervention for acute myocardial infarction
Autor: | Hilde E. Groot, Minke H. T. Hartman, Pim van der Harst, Youlan L. Gu, Ad F. M. van den Heuvel, Bart J. G. L. de Smet, Erik Lipsic |
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Přispěvatelé: | Cardiovascular Centre (CVC) |
Rok vydání: | 2015 |
Předmět: |
Male
Time Factors Heart disease medicine.medical_treatment PRIMARY ANGIOPLASTY Myocardial Infarction Biochemistry Leukocytes Immunology and Allergy Medicine Myocardial infarction Ultrasonography RISK INDIVIDUAL PARTICIPANT METAANALYSIS biology Hematology Middle Aged NO-REFLOW PHENOMENON C-Reactive Protein Cardiology Regression Analysis CLINICAL-IMPLICATIONS Female TIMI medicine.medical_specialty Immunology Myocardial Reperfusion HEART-DISEASE BLUSH GRADE Percutaneous Coronary Intervention LEFT-VENTRICULAR FUNCTION Internal medicine Humans cardiovascular diseases Interleukin 6 Molecular Biology Platelet Count business.industry C-reactive protein Percutaneous coronary intervention medicine.disease Receptors Interleukin-6 Solubility Case-Control Studies Multivariate Analysis Conventional PCI No reflow phenomenon biology.protein ANGIOGRAPHIC ASSESSMENT Soluble interleukin-6 receptor business |
Zdroj: | Cytokine, 73(2), 207-212 |
ISSN: | 1043-4666 |
Popis: | Aims: Interleukin-6 receptor (IL-6R) signalling has been suggested to play a causal role in the development and outcome of coronary heart disease (CHD). The aim of this study was to investigate the association of sIL-6R levels with myocardial reperfusion after percutaneous coronary intervention (PCI) for acute ST-elevated myocardial infarction (STEMI).Methods: Blood was sampled from 70 patients presenting with STEMI at 6 different time-points (baseline, post-PCI, t = 1 h, t = 6 h, t = 24 h, t = 2w). Coronary angiograms post-PCI were analysed for myocardial blush grade (MBG) as indicator of myocardial reperfusion. Serum IL-6 and sIL-6R were measured using IL-6 and sIL-6R enzyme-linked immunosorbent assays (ELISA).Results: sIL-6R levels fluctuated biphasic during the two weeks after STEMI. Reduced MBG was associated with a larger change in sIL-6R levels between baseline and post-PCI compared to optimal MBG (-13.40; SEM 2.78 ng/ml vs -1.99; SEM 2.35 ng/ml, respectively; p Conclusions: sIL-6R levels fluctuate biphasic during the two weeks after MI with larger changes and increased IL-6/sIL-6R ratio in patients with reduced MBG. Further research is needed to increase our understanding of the possible causality of these associations. (C) 2015 Elsevier Ltd. All rights reserved. |
Databáze: | OpenAIRE |
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