Epidemiological and Genotypical Features of HCV in District Upper Dir, Khyber Pakhtunkhwa, Pakistan
| Autor: | Khaista MUNİR, Muhammad Ajmal KHAN, Aftab AMİN, Bakhtawar KHAN, Atta UR RAHMAN, Amin ULLAH, Mukhtar ULLAH |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Volume: 11, Issue: 04 217-223 Journal of Microbiology and Infectious Diseases |
| ISSN: | 2146-3158 2146-9369 |
| DOI: | 10.5799/jmid.1036786 |
| Popis: | Objectives: Objective: The incidence of Hepatitis C Virus (HCV) infection is high in Pakistan. The current study evaluates HCV risk factors, epidemiology, and genotype distribution in the less-developed Upper Dir Region, Khyber Pakhtunkhwa Province (KPK), Pakistan. Methods: Blood samples from 500 outpatients from the Upper Dir Region were collected for initial screening using a strip-based immunochromatography test (ICT). In this study, ICT analysis followed Polymerase chain reaction (PCR) analysis for HCV-RNA confirmation. In addition, PCR positive samples were subject to genotypic description using genotype-specific primers.Results: ICT analysis revealed that out of 500 patients, 13 (2.6%) were HCV positive. PCR analysis identified that 10 (2.0%) of the 13 HCV-positive patients were HCV-RNA positive. The overall incidence of HCV in the study group was 2.6%. The rate of HCV incidence was found to be higher in males (10/339 participants, 3.0%), while a lower incidence was found in females (3 of 161 participants, 1.9%). The patients between 45 and 60 years had the highest incidence rate (6 of 53 participants, 11.3%, P |
| Databáze: | OpenAIRE |
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