Endothelin-1 stimulates human monocytes in vitro to release TNF-α , IL-1β and IL-6
| Autor: | R. Seljelid, T. Sildnes, E. Helset, Z. S. Konopski |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Immunology Inflammation Monocytes Internal medicine lcsh:Pathology medicine Macrophage Interleukin 6 Macrophage inflammatory protein IL-6 Endothelin-1 biology business.industry Macrophages Monocyte Cell Biology VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::Medical microbiology: 715 Endothelin 1 medicine.anatomical_structure Cytokine Endocrinology IL-1β TNF-α biology.protein Cytokines Tumor necrosis factor alpha medicine.symptom business lcsh:RB1-214 Research Article |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Vol 2, Iss 6, Pp 417-422 (1993) |
| ISSN: | 1466-1861 0962-9351 |
| DOI: | 10.1155/s0962935193000596 |
| Popis: | Increased plasma- and tissue levels of endothelin-1 (ET-1) during inflammatory diseases, have suggested a role of ET-1 in the pathophysiology of inflammatory reactions. The authors have studied the effect of ET-1 on cytokine release from monocytes and monocyte-derived macrophages. ET-1 increased secretion of TNF-alpha, IL-1beta and IL-6 in a dose- and time-dependent manner. Optimal ET-1 concentration ranged from 0.01 to 1 nM. The maximal response was a 200 to 400% increase in cytokine release. A time-course study revealed that the pattern of cytokines induced by ET-1 was different in monocytes and macrophages, although an early increase in TNF-alpha was observed in both monocyte and macrophage supernatants. In conclusion, ET-1 stimulates monocytes and macrophages to release cytokines thereby demonstrating a potential role for ET-1 in regulation of inflammatory responses. |
| Databáze: | OpenAIRE |
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