Long-range interactions in nonsense-mediated mRNA decay are mediated by intrinsically disordered protein regions
| Autor: | Peter Tompa, Veronika Acs, Lajos Kalmar, Daniel Silhavy |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Genetics
0303 health sciences Messenger RNA Protein Conformation Nonsense-mediated decay RNA MRNA Decay Computational Biology Plasma protein binding Biology Models Biological Cell biology Nonsense Mediated mRNA Decay 03 medical and health sciences 0302 clinical medicine Protein structure Structural Biology Multiprotein Complexes RNA Messenger Premature Termination Codon Molecular Biology 030217 neurology & neurosurgery 030304 developmental biology Protein Binding |
| Zdroj: | Journal of molecular biology. 424(3-4) |
| ISSN: | 1089-8638 |
| Popis: | In nonsense-mediated mRNA decay (NMD), large protein complexes cooperate to trigger degradation of mRNA with a premature termination codon. Due to the extreme variation in the size and topology of its mRNA substrate, the structural underpinning of the fidelity of NMD is little understood. Based on bioinformatic predictions, we suggest that fly-casting mechanisms enabled by long disordered regions in NMD complexes are exploited for the underlying effective long-range communication. |
| Databáze: | OpenAIRE |
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