Thromboembolic events in patients with inflammatory bowel disease
| Autor: | Youssef M.K. Farag, Mohamed Shoukri, Mohammad Hasan Rajab, Abdulrahman M. Aljebreen, Aamer S Aleem, Fouad Jabri, Farjah H. Algahtani, Nahla A Alazzam |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty pulmonary embolism venous thromboembolism Population Saudi Arabia Inflammatory bowel disease Consanguinity Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors inflammatory bowel disease Deep vein thrombosis Internal medicine Prevalence medicine Humans Prospective Studies lcsh:RC799-869 Family history Prospective cohort study education thrombosis Venous Thrombosis education.field_of_study business.industry Gastroenterology thromboembolism Inflammatory Bowel Diseases medicine.disease Thrombosis Ulcerative colitis Surgery Pulmonary embolism Venous thrombosis 030220 oncology & carcinogenesis Original Article Female lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology business |
| Zdroj: | The Saudi Journal of Gastroenterology, Vol 22, Iss 6, Pp 423-427 (2016) Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association |
| ISSN: | 1319-3767 |
| DOI: | 10.4103/1319-3767.195558 |
| Popis: | Background/Aims: Inflammatory bowel disease (ulcerative colitis and Crohn's disease) is characterized by a chronic inflammatory condition, and is accompanied by abnormalities in coagulation and a hyper-coagulable state. This study was conducted to examine the risk factors for developing Thromboembolic Events in Inflammatory Bowel Disease (IBD) in a population with prevalent consanguinity. Patients and Methods: Patients with a definitive diagnosis of IBD who were seen in the gastroenterology clinic of King Khalid University Hospital (Riyadh, Saudi Arabia) from 2010- to 2012, were asked to participate in this prospective cohort study, and were followed for one 1 year. Data was collected using specifically designed case report forms (CRF) by trained research personnel. Results: A total of 100 Saudi patients with IBD were studied. There were 51 (51%) women and the mean ± standard deviation (SD) age of the group was 31.24 ± 10.78 years. Those with Crohn's disease constituted 72% of the patients, and 28% had ulcerative colitis. Eight patients (8%) had at least one Thrombotic Event ([six deep venous thrombosis (DVT), and two pulmonary embolism (PE)]. Family history of deep venous thrombosis was present in 5%, and family history of pulmonary embolism (PE) in 4% of the patients. After adjusting for age and gender, a family history of Thrombotic event was identified as to be the only statistically significant predictor of thrombosis in IBD patients (RR = 9.22, 95% CI: 2.10--40.43). Conclusion: In a population with high consanguinity, Thromboembolic events (DVT and PE) had a prevalence of 8% among IBD patients, positive family history of pulmonary embolism was a predictor of thrombosis. Further studies are needed to explore the role of genetic factors in this population. |
| Databáze: | OpenAIRE |
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