Pathway to Deployment of Gene Drive Mosquitoes as a Potential Biocontrol Tool for Elimination of Malaria in Sub-Saharan Africa: Recommendations of a Scientific Working Group
| Autor: | Charles M. Mbogo, Yeya T. Touré, Brian Greenwood, Moussa Savadogo, Michael Gottlieb, Fredros O. Okumu, Claudia Emerson, Stephanie L. James, Philip A. Welkhoff, Jerome Amir Singh, Steve W. Lindsay, Karen H. Tountas, Frank H. Collins, H. Charles J. Godfray, Hector Quemada |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Anopheles gambiae Mosquito Vectors Biology 03 medical and health sciences Virology parasitic diseases medicine CRISPR Animals Pest Control Biological Africa South of the Sahara Vector control business.industry Gene Drive Technology Environmental exposure Gene drive Articles medicine.disease biology.organism_classification 3. Good health Malaria 030104 developmental biology Infectious Diseases Culicidae Risk analysis (engineering) New product development Parasitology business |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene American journal of tropical medicine and hygiene, 2018, Vol.98(6_Suppl), pp.1-49 [Peer Reviewed Journal] |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | Gene drive technology offers the promise for a high-impact, cost-effective, and durable method to control malaria transmission that would make a significant contribution to elimination. Gene drive systems, such as those based on clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein, have the potential to spread beneficial traits through interbreeding populations of malaria mosquitoes. However, the characteristics of this technology have raised concerns that necessitate careful consideration of the product development pathway. A multidisciplinary working group considered the implications of low-threshold gene drive systems on the development pathway described in the World Health Organization Guidance Framework for testing genetically modified (GM) mosquitoes, focusing on reduction of malaria transmission by Anopheles gambiae s.l. mosquitoes in Africa as a case study. The group developed recommendations for the safe and ethical testing of gene drive mosquitoes, drawing on prior experience with other vector control tools, GM organisms, and biocontrol agents. These recommendations are organized according to a testing plan that seeks to maximize safety by incrementally increasing the degree of human and environmental exposure to the investigational product. As with biocontrol agents, emphasis is placed on safety evaluation at the end of physically confined laboratory testing as a major decision point for whether to enter field testing. Progression through the testing pathway is based on fulfillment of safety and efficacy criteria, and is subject to regulatory and ethical approvals, as well as social acceptance. The working group identified several resources that were considered important to support responsible field testing of gene drive mosquitoes. |
| Databáze: | OpenAIRE |
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