Neurocognitive performance in relapsing-remitting multiple sclerosis patients is associated with metabolic abnormalities of the thalamus but not the hippocampus– GABA-edited 1H MRS study
| Autor: | Marian Grendar, Daniel Čierny, Petra Hnilicová, Egon Kurča, Kamil Zeleňák, Slavomíra Kováčová, Eva Heckova, Wolfgang Bogner, Ján Grossmann, Bernhard Strasser, Ema Kantorová |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Multiple Sclerosis Proton Magnetic Resonance Spectroscopy Thalamus Hippocampus Grey matter Creatine Gastroenterology chemistry.chemical_compound Multiple Sclerosis Relapsing-Remitting Internal medicine Humans Medicine gamma-Aminobutyric Acid business.industry Multiple sclerosis Glutamate receptor Neuropsychology General Medicine medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure nervous system Neurology chemistry Neurology (clinical) business Neurocognitive |
| Zdroj: | Neurological Research. 44:57-64 |
| ISSN: | 1743-1328 0161-6412 |
| DOI: | 10.1080/01616412.2021.1956282 |
| Popis: | Objectives Multiple sclerosis (MS) is an inflammatory demyelinating disease that may cause physical disabling as well as cognitive dysfunction. The presented study investigated how the neuropsychological status depends on the thalamus and hippocampus's metabolic processes, using γ-aminobutyric acid-edited magnetic resonance spectroscopy (GABA-edited 1H MRS) in patients with early MS, and how the results differ from healthy volunteers. Methods We recruited 36 relapsing-remitting (RRMS) MS patients and 22 controls (CON). In addition to common 1H MRS metabolites, such as N-acetyl-aspartate (tNAA), myoinositol (mIns), total choline and creatine (tCr, tCho), we also evaluated GABA and glutamate/glutamine (Glx). Metabolite ratios were correlated with the results of Single-Digit Modality Test (SDMT) and Expanded Disability Status Score (EDSS). Results In the thalamus, GABA ratios (GABA/tCr, GABA/tNAA) were significantly lower in RRMS patients than in CON. Both tCho- and mIns-ratios correlated with lower scores of SDMT but not with EDSS. Metabolic ratios in the hippocampus did not differ between RRMS and CON and did not correlate with any of performed tests. Discussion This study is the first to provide GABA-edited 1H MRS evidence for MS-related metabolic changes of the thalamus and hippocampus. The findings underline the importance of evaluating subcortical grey matter in MS patients to improve understanding of the clinical manifestations of MS and as a potential future target for treatment. |
| Databáze: | OpenAIRE |
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